Clinical Correlates of Weight Loss and Attrition During a 10-Week Dietary Intervention Study: Results from the NUGENOB Project

T. Handjieva-Darlenska, C. Holst, K. Grau, E. Blaak, J.A. Martinez, J.M. Oppert, M.A. Taylor, T.I. Sorensen, A. Astrup

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Abstract

Objective: The aim of this study was to identify the pre-treatment subject characteristics and weight loss changes as determinants of weight loss and attrition during a 10-week dietary intervention study. Methods: A total of 771 obese subjects (BMI 35.6 kg/m(2)) of both genders were included from 8 clinical centres in 7 European countries, who underwent a 10-week dietary intervention study comparing two hypo-energetic (-600 kcal/day) diets varying in fat content. Results: The multiple regression model showed that weight loss at week 10 was predicted by: 6.55 + 1.27 x early weight loss (kg) at week 1 + 1.35 x gender (R(2) = 0.28, p < 0.001). When performing the corresponding model with half-way weight loss (week 5) as covariate, the regression equation was: weight loss (kg) at week 10 = 1.88 + 1.38 x half-way weight loss (kg) (week 5) + 0.42 x gender (R(2) = 0.77, p < 0.001). A cut-off target of >/= 4 kg weight loss at week 5 emerged as an optimal predictor for reaching at least 10% weight loss at week 10. Greater attrition likelihood was predicted by high-fat diet, decreased early and half-way weight losses. Conclusion: Early and half-way weight losses are associated with and could contribute to prediction of the final weight loss and attrition. Copyright (c) 2012 S. Karger GmbH, Freiburg.
Original languageEnglish
Pages (from-to)928-936
Number of pages9
JournalObesity Facts
Volume5
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Correlates
  • Early weight loss
  • Half-way weight loss
  • Attrition
  • Gender
  • TERM-FOLLOW-UP
  • OBESITY TREATMENT
  • BODY-COMPOSITION
  • MORBID-OBESITY
  • PRETREATMENT PREDICTORS
  • HEALTH IMPLICATIONS
  • SPOUSE INVOLVEMENT
  • DIABETIC-PATIENTS
  • LOSS MAINTENANCE
  • MUSCLE STRENGTH

Cite this

Handjieva-Darlenska, T., Holst, C., Grau, K., Blaak, E., Martinez, J. A., Oppert, J. M., Taylor, M. A., Sorensen, T. I., & Astrup, A. (2012). Clinical Correlates of Weight Loss and Attrition During a 10-Week Dietary Intervention Study: Results from the NUGENOB Project. Obesity Facts, 5(6), 928-936. https://doi.org/10.1159/000345951