Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group

A.A. Loosdrecht; W. Kern; A. Porwit; P. Valent; S. Kordasti; E. Cremers; C. Alhan; C. Duetz; A. Dunlop; W. Hobo; F. Preijers; O. Wagner-Ballon; N. Chapuis; M. Fontenay; P. Bettelheim; L. Eidenschink-Brodersen; P. Font; U. Johansson; M.R. Loken; J.G. Marvelde; S. Matarraz; K. Ogata; U. Oelschlaegel; A. Orfao; K. Psarra; D. Subira; D.A. Wells; M.C. Bene; M.G. Della Porta; K. Burbury; F. Bellos; V.H.J. van der Velden; T.M. Westers; L. Saft; R. Ireland

doi:10.1002/cyto.b.22044

Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group

A.A. Loosdrecht^*, W. Kern, A. Porwit, P. Valent, S. Kordasti, E. Cremers, C. Alhan, C. Duetz, A. Dunlop, W. Hobo, F. Preijers, O. Wagner-Ballon, N. Chapuis, M. Fontenay, P. Bettelheim, L. Eidenschink-Brodersen, P. Font, U. Johansson, M.R. Loken, J.G. MarveldeS. Matarraz, K. Ogata, U. Oelschlaegel, A. Orfao, K. Psarra, D. Subira, D.A. Wells, M.C. Bene, M.G. Della Porta, K. Burbury, F. Bellos, V.H.J. van der Velden, T.M. Westers, L. Saft, R. Ireland

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Web of Science)

Abstract

This article discusses the rationale for inclusion of flow cytometry (FCM) in the diagnostic investigation and evaluation of cytopenias of uncertain origin and suspected myelodysplastic syndromes (MDS) by the European LeukemiaNet international MDS Flow Working Group (ELN iMDS Flow WG). The WHO 2016 classification recognizes that FCM contributes to the diagnosis of MDS and may be useful for prognostication, prediction, and evaluation of response to therapy and follow-up of MDS patients.

Original language	English
Pages (from-to)	77-86
Number of pages	10
Journal	Cytometry Part B-clinical Cytometry
Volume	104
Issue number	1
Early online date	13 Dec 2021
DOIs	https://doi.org/10.1002/cyto.b.22044
Publication status	Published - Jan 2023

Keywords

consensus
ELN
flow cytometry
myelodysplastic syndromes
standardization
PROGNOSTIC SCORING SYSTEM
CLASSIFICATION
DIAGNOSIS
CYTOGENETICS
CELLS
STANDARDIZATION
CYTOMORPHOLOGY
VALIDATION
CONSORTIUM
SUBGROUPS

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Cite this

Loosdrecht, A. A., Kern, W., Porwit, A., Valent, P., Kordasti, S., Cremers, E., Alhan, C., Duetz, C., Dunlop, A., Hobo, W., Preijers, F., Wagner-Ballon, O., Chapuis, N., Fontenay, M., Bettelheim, P., Eidenschink-Brodersen, L., Font, P., Johansson, U., Loken, M. R., ... Ireland, R. (2023). Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group. Cytometry Part B-clinical Cytometry, 104(1), 77-86. https://doi.org/10.1002/cyto.b.22044

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abstract = "This article discusses the rationale for inclusion of flow cytometry (FCM) in the diagnostic investigation and evaluation of cytopenias of uncertain origin and suspected myelodysplastic syndromes (MDS) by the European LeukemiaNet international MDS Flow Working Group (ELN iMDS Flow WG). The WHO 2016 classification recognizes that FCM contributes to the diagnosis of MDS and may be useful for prognostication, prediction, and evaluation of response to therapy and follow-up of MDS patients.",

keywords = "consensus, ELN, flow cytometry, myelodysplastic syndromes, standardization, PROGNOSTIC SCORING SYSTEM, CLASSIFICATION, DIAGNOSIS, CYTOGENETICS, CELLS, STANDARDIZATION, CYTOMORPHOLOGY, VALIDATION, CONSORTIUM, SUBGROUPS",

author = "A.A. Loosdrecht and W. Kern and A. Porwit and P. Valent and S. Kordasti and E. Cremers and C. Alhan and C. Duetz and A. Dunlop and W. Hobo and F. Preijers and O. Wagner-Ballon and N. Chapuis and M. Fontenay and P. Bettelheim and L. Eidenschink-Brodersen and P. Font and U. Johansson and M.R. Loken and J.G. Marvelde and S. Matarraz and K. Ogata and U. Oelschlaegel and A. Orfao and K. Psarra and D. Subira and D.A. Wells and M.C. Bene and {Della Porta}, M.G. and K. Burbury and F. Bellos and {van der Velden}, V.H.J. and T.M. Westers and L. Saft and R. Ireland",

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Loosdrecht, AA, Kern, W, Porwit, A, Valent, P, Kordasti, S, Cremers, E, Alhan, C, Duetz, C, Dunlop, A, Hobo, W, Preijers, F, Wagner-Ballon, O, Chapuis, N, Fontenay, M, Bettelheim, P, Eidenschink-Brodersen, L, Font, P, Johansson, U, Loken, MR, Marvelde, JG, Matarraz, S, Ogata, K, Oelschlaegel, U, Orfao, A, Psarra, K, Subira, D, Wells, DA, Bene, MC, Della Porta, MG, Burbury, K, Bellos, F, van der Velden, VHJ, Westers, TM, Saft, L & Ireland, R 2023, 'Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group', Cytometry Part B-clinical Cytometry, vol. 104, no. 1, pp. 77-86. https://doi.org/10.1002/cyto.b.22044

Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group. / Loosdrecht, A.A.; Kern, W.; Porwit, A. et al.

In: Cytometry Part B-clinical Cytometry, Vol. 104, No. 1, 01.2023, p. 77-86.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Valent, P.

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AU - Della Porta, M.G.

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KW - ELN

KW - flow cytometry

KW - myelodysplastic syndromes

KW - standardization

KW - PROGNOSTIC SCORING SYSTEM

KW - CLASSIFICATION

KW - DIAGNOSIS

KW - CYTOGENETICS

KW - CELLS

KW - STANDARDIZATION

KW - CYTOMORPHOLOGY

KW - VALIDATION

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Loosdrecht AA, Kern W, Porwit A, Valent P, Kordasti S, Cremers E et al. Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS-Flow Cytometry Working Group. Cytometry Part B-clinical Cytometry. 2023 Jan;104(1):77-86. Epub 2021 Dec 13. doi: 10.1002/cyto.b.22044