Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome

K.N. Shudofsky; P.K.C. Janssen; N. Foudraine; J.L.M.L. le Noble

doi:10.1002/jcph.2005

Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome

K.N. Shudofsky
, P.K.C. Janssen
, N. Foudraine
, J.L.M.L. le Noble^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Original language	English
Pages (from-to)	568-570
Number of pages	3
Journal	Journal of Clinical Pharmacology
Volume	62
Issue number	4
Early online date	3 Jan 2022
DOIs	https://doi.org/10.1002/jcph.2005
Publication status	Published - Apr 2022

Keywords

Conjugated metabolites
Continuous venovenous hemofiltration
COVID-19
Lormetazepam
Midazolam
Prolonged sedation
INTENSIVE-CARE PATIENTS
POPULATION PHARMACOKINETICS

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Shudofsky, K. N., Janssen, P. K. C., Foudraine, N., & le Noble, J. L. M. L. (2022). Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome. Journal of Clinical Pharmacology, 62(4), 568-570. https://doi.org/10.1002/jcph.2005

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title = "Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome",

keywords = "Conjugated metabolites, Continuous venovenous hemofiltration, COVID-19, Lormetazepam, Midazolam, Prolonged sedation, INTENSIVE-CARE PATIENTS, POPULATION PHARMACOKINETICS",

author = "K.N. Shudofsky and P.K.C. Janssen and N. Foudraine and \{le Noble\}, J.L.M.L.",

note = "Funding Information: The authors thank the laboratory analysts, Hai Holthuysen, Sandra Peters, and Marissa Janssen, at the Department of Clinical Pharmacy, VieCuri Medical Centre, Venlo, for performing laboratory tests.",

year = "2022",

month = apr,

doi = "10.1002/jcph.2005",

language = "English",

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Shudofsky, KN, Janssen, PKC, Foudraine, N & le Noble, JLML 2022, 'Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome', Journal of Clinical Pharmacology, vol. 62, no. 4, pp. 568-570. https://doi.org/10.1002/jcph.2005

Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome. / Shudofsky, K.N.; Janssen, P.K.C.; Foudraine, N. et al.
In: Journal of Clinical Pharmacology, Vol. 62, No. 4, 04.2022, p. 568-570.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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T1 - Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome

AU - Shudofsky, K.N.

AU - Janssen, P.K.C.

AU - Foudraine, N.

AU - le Noble, J.L.M.L.

N1 - Funding Information: The authors thank the laboratory analysts, Hai Holthuysen, Sandra Peters, and Marissa Janssen, at the Department of Clinical Pharmacy, VieCuri Medical Centre, Venlo, for performing laboratory tests.

PY - 2022/4

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KW - Conjugated metabolites

KW - Continuous venovenous hemofiltration

KW - COVID-19

KW - Lormetazepam

KW - Midazolam

KW - Prolonged sedation

KW - INTENSIVE-CARE PATIENTS

KW - POPULATION PHARMACOKINETICS

U2 - 10.1002/jcph.2005

DO - 10.1002/jcph.2005

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SN - 0091-2700

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JO - Journal of Clinical Pharmacology

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Shudofsky KN, Janssen PKC, Foudraine N, le Noble JLML. Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome. Journal of Clinical Pharmacology. 2022 Apr;62(4):568-570. Epub 2022 Jan 3. doi: 10.1002/jcph.2005