@article{50b9cb1f7694477e965211ed5afde097,
title = "Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy",
abstract = "Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease characterized by progressive myocardial fibro-fatty replacement, arrhythmias and risk of sudden death. Its diagnosis is challenging and often it is achieved after disease onset or postmortem. In this study, we sought to identify circulating microRNAs (miRNAs) differentially expressed in ARVC patients compared to healthy controls. In the pilot study, we screened the expression of 754 miRNAs from 21 ARVC patients and 20 healthy controls. After filtering the miRNAs considering a log fold-change cut-off of & PLUSMN;1, p-value < 0.05, we selected five candidate miRNAs for a subsequent validation study in which we used TaqMan-based real-time PCR to analyse samples from 37 ARVC patients and 30 healthy controls. We found miR-185-5p significantly upregulated in ARVC patients. Receiver operating characteristic analysis indicated an area under the curve of 0.854, corroborating the link of this miRNA and ARVC pathophysiology.",
keywords = "MICRORNA, MicroRNAs, arrhythmogenic right ventricular cardiomyopathy, biomarkers, circulating microRNAs, genetics, heart failure",
author = "C. Sacchetto and Z. Mohseni and R.M.W. Colpaert and L. Vitiello and {De Bortoli}, M. and I.G.C. Vonhogen and K. Xiao and G. Poloni and A. Lorenzon and C. Romualdi and R. Bariani and E. Mazzotti and L. Daliento and B. Bauce and D. Corrado and T. Thum and A. Rampazzo and {de Windt}, L.J. and M. Calore",
note = "Funding Information: Funding: L.J.d.W. and M.C. acknowledge support from the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, ZonMW and the Royal Netherlands Academy of Sciences (DCVA2017-2018ARENA-PRIME). L.J.d.W. was supported by grant 311549 from the European Research Council (ERC), a VICI award 918-156-47 from the Dutch Research Council (NWO) and the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No 813716. Z.M. was supported by the selective Student grant 2019SB002 from the Dutch Heart Foundation. A.R. was supported by TRANSAC Strategic Research Grant CPDA133979/13, University of Padua, Italy. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = oct,
day = "1",
doi = "10.3390/cells10102578",
language = "English",
volume = "10",
journal = "Cells",
issn = "2073-4409",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",
}