@article{0cdda2ca7e554c659d67dc369c793224,
title = "Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort",
abstract = "Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.",
keywords = "alcohol, targeted metabolomics, lipid metabolites, amino acids, acylcarnitines, FALSE DISCOVERY RATE, PHYSICAL-ACTIVITY, CONSUMPTION, METABOLOMICS, PLASMA, RISK, ACID, SPHINGOMYELINASE, POPULATIONS, APOPTOSIS, Life Style, Prospective Studies, Humans, Middle Aged, Male, Chromatography, High Pressure Liquid, Smoking/adverse effects, Tandem Mass Spectrometry, Biotransformation, Biomarkers/blood, Female, Nutritional Status, Alcohol Drinking/adverse effects, Europe, Risk Factors, Self Report, Sex Factors, Aged, Lipids/blood, Metabolomics/methods, Neoplasms/blood",
author = "{van Roekel}, {Eline H.} and Laura Trijsburg and Nada Assi and Marion Carayol and David Achaintre and Neil Murphy and Sabina Rinaldi and Schmidt, {Julie A.} and Magdalena Stepien and Rudolf Kaaks and Tilman Kuhn and Heiner Boeing and Khalid Iqbal and Domenico Palli and Vittorio Krogh and Rosario Tumino and Fulvio Ricceri and Salvatore Panico and Peeters, {Petra H.} and Bas Bueno-de-Mesquita and Eva Ardanaz and Leila Lujan-Barroso and J. Quiros and Huerta, {Jose M.} and Elena Molina-Portillo and Miren Dorronsoro and Tsilidis, {Konstantinos K.} and Elio Riboli and Rostgaard-Hansen, {Agnetha Linn} and Anne Tjonneland and Kim Overvad and Elisabete Weiderpass and Marie-Christine Boutron-Ruault and Gianluca Severi and Antonia Trichopoulou and Anna Karakatsani and Anastasia Kotanidou and Anders Hakansson and Johan Malm and Weijenberg, {Matty P.} and Gunter, {Marc J.} and Mazda Jenab and Mattias Johansson and Travis, {Ruth C.} and Augustin Scalbert and Pietro Ferrari",
year = "2018",
month = may,
day = "22",
doi = "10.3390/nu10050654",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",
}