Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

B.A. van Dijk, L.J. Schouten, E. Oosterwijk, C.A. Hulsbergen van de Kaa, L.A. Kiemeney, R.A. Goldbohm, J.A. Schalken, P.A. van den Brandt

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Abstract

We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations. AD - Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands.
Original languageEnglish
Pages (from-to)374-377
JournalBritish Journal of Cancer
Volume95
Issue number3
DOIs
Publication statusPublished - 1 Jan 2006

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