Chylomicron synthesis by intestinal cells in vitro and in vivo.

M.M.J. van Greevenbroek, T.W.A. de Bruin

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Abstract

Laboratory for Molecular Metabolism and Endocrinology, Maastricht University, The Netherlands.

Synthesis and secretion of chylomicrons by the intestine is essential to transport dietary fats in the circulation and to deliver these fats to the appropriate peripheral tissues. The assembly of chylomicrons within the enterocyte and the subsequent secretion of these lipoprotein particles into the lymph is a complex, multi-step process that includes absorption of lipids by the enterocytes, cellular lipid (re)synthesis and translocation of cellular lipid pools, synthesis and post-translational modification of various apolipoproteins and, finally, the assembly of lipid and lipoprotein components into a chylomicron. The key process in chylomicron synthesis is the intracellular association of apolipoprotein (apo)B48, the structural protein of chylomicrons, with lipids.

Publication Types:
Review
Review, Tutorial
Original languageEnglish
Pages (from-to)S9-S16
Number of pages8
JournalAtherosclerosis
Volume141
Issue numberSuppl.
DOIs
Publication statusPublished - 1 Jan 1998

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