Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives

T. Strekalova*, Y.Z. Liu, D. Kiselev, S. Khairuddin, J.L.Y. Chiu, J. Lam*, Y.S. Chan, D. Pavlov, A. Proshin, K.P. Lesch, D.C. Anthony, L.W. Lim*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Web of Science)
Original languageEnglish
Pages (from-to)663-693
Number of pages31
JournalPsychopharmacology
Volume239
Issue number3
Early online date24 Jan 2022
DOIs
Publication statusPublished - Mar 2022

Keywords

  • Chronic mild stress (CMS)
  • Depression
  • Sucrose test
  • Anhedonia
  • Forced swimming
  • Open field
  • Inter-individual variability
  • Stress resilience
  • Rat
  • ANXIETY-LIKE BEHAVIOR
  • ANTIDEPRESSANT-LIKE ACTIVITY
  • MALE WISTAR RATS
  • FORCED-SWIM TEST
  • ANIMAL-MODELS
  • INDUCED ANHEDONIA
  • UNPREDICTABLE STRESS
  • SUCROSE CONSUMPTION
  • HEART-RATE
  • PREFRONTAL CORTEX

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