TY - JOUR
T1 - Choroidal Microvascular Dropout in Pseudoexfoliation Glaucoma
AU - Pradhan, Zia S.
AU - Rao, Harsha L.
AU - Dixit, Shivani
AU - Sreenivasaiah, Shruthi
AU - Reddy, Praveena G.
AU - Venugopal, Jayasree P.
AU - Puttaiah, Narendra K.
AU - Devi, Sathi
AU - Weinreb, Robert N.
AU - Mansouri, Kaweh
AU - Webers, Carroll A. B.
N1 - Funding Information:
Supported in part by National Institutes of Health (Bethesda, MD, USA) EY029058 (RNW) and an unrestricted grant from Research to Prevent Blindness (New York, NY, USA). Disclosure: Z.S. Pradhan, None; H.L. Rao, Allergan (C), Santen (C), Meditec-Zeiss (C); S. Dixit, None; S. Sreenivasaiah, None; P.G. Reddy, None; J.P. Venugopal, None; N.K. Puttaiah, None;
Publisher Copyright:
© 2019 The Authors.
PY - 2019/5
Y1 - 2019/5
N2 - PURPOSE. To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes.METHODS. In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coherence tomography and optical coherence tomography angiography examination. Peripapillary vessel density (VD) was evaluated from the radial peripapillary capillary slab, parafoveal VD was measured on the superficial vascular plexus slab of the macula, and CMvD was evaluated on the choroidal slabs of the optic disc scan.RESULTS. The PXG and POAG groups were similar with respect to average mean deviation on visual fields (-12.1 vs. -12.0 decibel, P = 0.96) and average peripapillary retinal nerve fiber layer thickness on optical coherence tomography (71 vs. 74 mu, P = 0.29). Average peripapillary superficial VD (49.7% vs. 51.3%, P = 0.35) and parafoveal VD (44.8% vs. 45.8%, P = 0.33) were similar between the PXG and POAG groups. CMvD was seen in 18 PXG and 31 POAG eyes (46.2% vs. 79.5%, P = 0.002). On multivariate analysis that accounted for the severity of glaucoma, the odds of CMvD was significantly lower in the PXG group when compared with the POAG group (odds ratio: 0.18-0.21, P <0.01).CONCLUSIONS. The prevalence of CMvD was significantly lower in the PXG eyes when compared with the POAG eyes.
AB - PURPOSE. To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes.METHODS. In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coherence tomography and optical coherence tomography angiography examination. Peripapillary vessel density (VD) was evaluated from the radial peripapillary capillary slab, parafoveal VD was measured on the superficial vascular plexus slab of the macula, and CMvD was evaluated on the choroidal slabs of the optic disc scan.RESULTS. The PXG and POAG groups were similar with respect to average mean deviation on visual fields (-12.1 vs. -12.0 decibel, P = 0.96) and average peripapillary retinal nerve fiber layer thickness on optical coherence tomography (71 vs. 74 mu, P = 0.29). Average peripapillary superficial VD (49.7% vs. 51.3%, P = 0.35) and parafoveal VD (44.8% vs. 45.8%, P = 0.33) were similar between the PXG and POAG groups. CMvD was seen in 18 PXG and 31 POAG eyes (46.2% vs. 79.5%, P = 0.002). On multivariate analysis that accounted for the severity of glaucoma, the odds of CMvD was significantly lower in the PXG group when compared with the POAG group (odds ratio: 0.18-0.21, P <0.01).CONCLUSIONS. The prevalence of CMvD was significantly lower in the PXG eyes when compared with the POAG eyes.
KW - choroidal microvascular dropout
KW - optical coherence tomography angiography
KW - pseudoexfoliation glaucoma
KW - primary open angle glaucoma
KW - COHERENCE TOMOGRAPHY ANGIOGRAPHY
KW - OPTIC DISC PERFUSION
KW - VESSEL DENSITY
KW - VISUAL-FIELD
KW - SEVERITY
KW - HEALTHY
U2 - 10.1167/iovs.19-26844
DO - 10.1167/iovs.19-26844
M3 - Article
C2 - 31108546
SN - 0146-0404
VL - 60
SP - 2146
EP - 2151
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
IS - 6
ER -