TY - JOUR
T1 - Choroidal Microvascular Dropout in Primary Open-angle Glaucoma Eyes With Disc Hemorrhage
AU - Rao, Harsha L.
AU - Sreenivasaiah, Shruthi
AU - Dixit, Shivani
AU - Riyazuddin, Mohammed
AU - Dasari, Srilakshmi
AU - Venugopal, Jayasree P.
AU - Pradhan, Zia S.
AU - Puttaiah, Narendra K.
AU - Devi, Sathi
AU - Mansouri, Kaweh
AU - Webers, Carroll A. B.
AU - Weinreb, Robert N.
N1 - Funding Information:
Supported in part by R01 EY029058 (R.N.W.) for the National Eye Institute and an unrestricted grant from Research to Prevent Blind-ness (NY, New York).
Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - Purpose: The main purpose of this study was to compare the prevalence of choroidal microvascular dropout (CMvD) in primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH). Methods: In a cross-sectional study, 44 eyes of 44 control subjects, 32 eyes of 32 POAG patients with DH, and 41 eyes of 41 POAG patients without DH underwent visual fields (VFs), optical coherence tomography (OCT) and OCT angiography (OCTA). Presence of CMvD was evaluated on the choroidal OCTA slab. VF defect in the glaucoma eyes were classified into initial nasal defect, initial parafoveal scotoma, and combined nasal and parafoveal defect. Results: CMvD was detected in 17 POAG eyes with DH (53.1%) and 13 POAG eyes without DH (31.7%; P=0.06). On univariate analysis, CMvD in POAG eyes was associated with DH [odds ratio (OR): 2.44, P=0.06] and measures of glaucoma severity: VF mean deviation (OR: 0.85, P=0.02), retinal nerve fiber layer thickness (OR: 0.95, P=0.03), and peripapillary vessel density (OR: 0.94, P=0.09). On multivariate models that accounted for the measures of glaucoma severity, CMvD in POAG eyes was statistically significantly associated with DH (OR >= 3, P
AB - Purpose: The main purpose of this study was to compare the prevalence of choroidal microvascular dropout (CMvD) in primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH). Methods: In a cross-sectional study, 44 eyes of 44 control subjects, 32 eyes of 32 POAG patients with DH, and 41 eyes of 41 POAG patients without DH underwent visual fields (VFs), optical coherence tomography (OCT) and OCT angiography (OCTA). Presence of CMvD was evaluated on the choroidal OCTA slab. VF defect in the glaucoma eyes were classified into initial nasal defect, initial parafoveal scotoma, and combined nasal and parafoveal defect. Results: CMvD was detected in 17 POAG eyes with DH (53.1%) and 13 POAG eyes without DH (31.7%; P=0.06). On univariate analysis, CMvD in POAG eyes was associated with DH [odds ratio (OR): 2.44, P=0.06] and measures of glaucoma severity: VF mean deviation (OR: 0.85, P=0.02), retinal nerve fiber layer thickness (OR: 0.95, P=0.03), and peripapillary vessel density (OR: 0.94, P=0.09). On multivariate models that accounted for the measures of glaucoma severity, CMvD in POAG eyes was statistically significantly associated with DH (OR >= 3, P
KW - glaucoma
KW - disc hemorrhage
KW - optical coherence tomography angiography
KW - choroidal microvascular dropout
KW - COHERENCE TOMOGRAPHY ANGIOGRAPHY
KW - VESSEL DENSITY
KW - RISK-FACTORS
KW - ASSOCIATION
KW - PROGRESSION
KW - PERFUSION
KW - SEVERITY
KW - DEFECTS
KW - DAMAGE
U2 - 10.1097/IJG.0000000000001173
DO - 10.1097/IJG.0000000000001173
M3 - Article
C2 - 30601223
SN - 1057-0829
VL - 28
SP - 181
EP - 187
JO - Journal of Glaucoma
JF - Journal of Glaucoma
IS - 3
ER -