Choroidal Microvascular Dropout in Primary Open-angle Glaucoma Eyes With Disc Hemorrhage

Harsha L. Rao*, Shruthi Sreenivasaiah, Shivani Dixit, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P. Venugopal, Zia S. Pradhan, Narendra K. Puttaiah, Sathi Devi, Kaweh Mansouri, Carroll A. B. Webers, Robert N. Weinreb

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Purpose: The main purpose of this study was to compare the prevalence of choroidal microvascular dropout (CMvD) in primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH). Methods: In a cross-sectional study, 44 eyes of 44 control subjects, 32 eyes of 32 POAG patients with DH, and 41 eyes of 41 POAG patients without DH underwent visual fields (VFs), optical coherence tomography (OCT) and OCT angiography (OCTA). Presence of CMvD was evaluated on the choroidal OCTA slab. VF defect in the glaucoma eyes were classified into initial nasal defect, initial parafoveal scotoma, and combined nasal and parafoveal defect. Results: CMvD was detected in 17 POAG eyes with DH (53.1%) and 13 POAG eyes without DH (31.7%; P=0.06). On univariate analysis, CMvD in POAG eyes was associated with DH [odds ratio (OR): 2.44, P=0.06] and measures of glaucoma severity: VF mean deviation (OR: 0.85, P=0.02), retinal nerve fiber layer thickness (OR: 0.95, P=0.03), and peripapillary vessel density (OR: 0.94, P=0.09). On multivariate models that accounted for the measures of glaucoma severity, CMvD in POAG eyes was statistically significantly associated with DH (OR >= 3, P

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalJournal of Glaucoma
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • glaucoma
  • disc hemorrhage
  • optical coherence tomography angiography
  • choroidal microvascular dropout
  • COHERENCE TOMOGRAPHY ANGIOGRAPHY
  • VESSEL DENSITY
  • RISK-FACTORS
  • ASSOCIATION
  • PROGRESSION
  • PERFUSION
  • SEVERITY
  • DEFECTS
  • DAMAGE

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