TY - JOUR
T1 - Choroidal Microvascular Dropout in Primary Angle Closure Glaucoma
AU - Rao, Harsha L.
AU - Sreenivasaiah, Shruthi
AU - Riyazuddin, Mohammed
AU - Dasari, Srilakshmi
AU - Dixit, Shivani
AU - Venugopal, Jayasree P.
AU - Pradhan, Zia S.
AU - Puttaiah, Narendra K.
AU - Devi, Sathi
AU - Weinreb, Robert N.
AU - Mansouri, Kaweh
AU - Webers, Carroll A. B.
N1 - Funding Information:
Funding: Supported in part by R01 EY029058 (R.N.W.) for the National Eye Institute and an unrestricted grant from Research to Prevent Blindness (New York, New York, USA). Financial Disclosures: Harsha L. Rao: Allergan (Consultant [C]); Robert N. Weinreb: Optovue (Research Support [S]), Meditec-Zeiss (S), Heidelberg Engineering (S), Genentech (S), Allergan (C), Alcon (C), Eyenovia (C), Bausch & Lomb (C), Sensimed (C), Unity (C); Kaweh Mansouri: Santen (C), Sensimed (C), Topcon (S), Alcon (S); Carroll A.B. Webers: Alcon (S), Allergan (C), Pfizer (C), Santen (C). The following authors have no financial disclosures: Shruthi Sreenivasaiah, Mohammed Riyazuddin, Srilakshmi Dasari, Shivani Dixit, Jayasree P. Venugopal, Zia S. Pradhan, Narendra K. Puttaiah, and Sathi Devi. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3
Y1 - 2019/3
N2 - PURPOSE: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes.DESIGN: Cross-sectional study.METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. Visual field (VF) defects in the glaucoma eyes were classified into initial nasal defect (IND), initial parafoveal scotoma (IPFS), and combined nasal and parafoveal defect, and the association between type of VF defect and CMvD was evaluated.RESULTS: CMvD was detected in 21 POAG (58.3%) and 10 PACG (35.7%) eyes (P = .07). CMvD in POAG eyes was associated with pretreatment intraocular pressure (odds ratio [OR] = 0.91/mm Hg higher intraocular pressure, P = .06), VF mean deviation (MD, OR = 0.75/dB higher MD, P = .007), retinal nerve fiber layer thickness (OR = 0.92/mu m increase in thickness, P = .02), and peripapillary vessel density (OR = 0.80/ unit increase in density, P = .01). CMvD in PACG eyes was associated only with VF MD (OR = 0.90/dB higher MD, P = .05). When analyzed in the entire cohort of glaucoma patients (64 eyes), CMvD was significantly associated with POAG (OR > 3.5, P <.05) after accounting for glaucoma severity. CMvD was seen in 6 of 7 eyes with IPFS and 1 of 13 with IND in the POAG group (P <.05) and 1 of 2 eyes with IPFS and 0 of 10 with IND in the PACG group (P <.05).CONCLUSIONS: Prevalence of CMvD was significantly lower in PACG compared to POAG. As in POAG, CMvD in PACG was associated with advanced VF damage and with IPFS on VF. (C) 2018 Elsevier Inc. All rights reserved.
AB - PURPOSE: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes.DESIGN: Cross-sectional study.METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. Visual field (VF) defects in the glaucoma eyes were classified into initial nasal defect (IND), initial parafoveal scotoma (IPFS), and combined nasal and parafoveal defect, and the association between type of VF defect and CMvD was evaluated.RESULTS: CMvD was detected in 21 POAG (58.3%) and 10 PACG (35.7%) eyes (P = .07). CMvD in POAG eyes was associated with pretreatment intraocular pressure (odds ratio [OR] = 0.91/mm Hg higher intraocular pressure, P = .06), VF mean deviation (MD, OR = 0.75/dB higher MD, P = .007), retinal nerve fiber layer thickness (OR = 0.92/mu m increase in thickness, P = .02), and peripapillary vessel density (OR = 0.80/ unit increase in density, P = .01). CMvD in PACG eyes was associated only with VF MD (OR = 0.90/dB higher MD, P = .05). When analyzed in the entire cohort of glaucoma patients (64 eyes), CMvD was significantly associated with POAG (OR > 3.5, P <.05) after accounting for glaucoma severity. CMvD was seen in 6 of 7 eyes with IPFS and 1 of 13 with IND in the POAG group (P <.05) and 1 of 2 eyes with IPFS and 0 of 10 with IND in the PACG group (P <.05).CONCLUSIONS: Prevalence of CMvD was significantly lower in PACG compared to POAG. As in POAG, CMvD in PACG was associated with advanced VF damage and with IPFS on VF. (C) 2018 Elsevier Inc. All rights reserved.
KW - OPTICAL COHERENCE TOMOGRAPHY
KW - ANGIOGRAPHY VESSEL DENSITY
KW - PERIPAPILLARY RETINA
KW - DISC PERFUSION
KW - SEVERITY
KW - DEFECTS
KW - DAMAGE
U2 - 10.1016/j.ajo.2018.11.021
DO - 10.1016/j.ajo.2018.11.021
M3 - Article
C2 - 30552893
SN - 0002-9394
VL - 199
SP - 184
EP - 192
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -