Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening

Aniruddha Agarwal; Federico Corvi; Nitin Kumar Menia; Kanika Aggarwal; Roel J Erckens; Tos T J M Berendschot; Carroll A B Webers; Alessandro Invernizzi; Vishali Gupta; SriniVas Sadda

doi:10.1080/09273948.2022.2140296

Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening

Aniruddha Agarwal^*
, Federico Corvi
, Nitin Kumar Menia
, Kanika Aggarwal
, Roel J Erckens
, Tos T J M Berendschot
, Carroll A B Webers
, Alessandro Invernizzi
, Vishali Gupta
, SriniVas Sadda

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC).

METHODS: In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW).

RESULTS: Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001).

CONCLUSIONS: Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.

Original language	English
Pages (from-to)	898-904
Number of pages	7
Journal	Ocular Immunology and Inflammation
Volume	32
Issue number	6
Early online date	3 Nov 2022
DOIs	https://doi.org/10.1080/09273948.2022.2140296
Publication status	Published - 2 Jul 2024

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Agarwal, A., Corvi, F., Kumar Menia, N., Aggarwal, K., Erckens, R. J., Berendschot, T. T. J. M., Webers, C. A. B., Invernizzi, A., Gupta, V., & Sadda, S. (2024). Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening. Ocular Immunology and Inflammation, 32(6), 898-904. https://doi.org/10.1080/09273948.2022.2140296

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title = "Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening",

abstract = "PURPOSE: The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC).METHODS: In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW).RESULTS: Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3\% on OCTA in eyes without PW and 35.4 ± 5.0\% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9\% and 28.0 ± 4.2\% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4\% and 48.8 ± 4.1\% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001).CONCLUSIONS: Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.",

author = "Aniruddha Agarwal and Federico Corvi and \{Kumar Menia\}, Nitin and Kanika Aggarwal and Erckens, \{Roel J\} and Berendschot, \{Tos T J M\} and Webers, \{Carroll A B\} and Alessandro Invernizzi and Vishali Gupta and SriniVas Sadda",

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doi = "10.1080/09273948.2022.2140296",

language = "English",

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T1 - Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening

AU - Agarwal, Aniruddha

AU - Corvi, Federico

AU - Kumar Menia, Nitin

AU - Aggarwal, Kanika

AU - Erckens, Roel J

AU - Berendschot, Tos T J M

AU - Webers, Carroll A B

AU - Invernizzi, Alessandro

AU - Gupta, Vishali

AU - Sadda, SriniVas

PY - 2024/7/2

Y1 - 2024/7/2

N2 - PURPOSE: The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC).METHODS: In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW).RESULTS: Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001).CONCLUSIONS: Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.

AB - PURPOSE: The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC).METHODS: In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW).RESULTS: Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001).CONCLUSIONS: Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.

U2 - 10.1080/09273948.2022.2140296

DO - 10.1080/09273948.2022.2140296

M3 - Article

C2 - 36328764

SN - 0927-3948

VL - 32

SP - 898

EP - 904

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 6

ER -

Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening

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