@article{8ed2c981c41a4e939ca25563712f7ed3,
title = "Choice of second-line systemic therapy in stage IV small cell lung cancer (SCLC) - A decision-making analysis amongst European lung cancer experts",
abstract = "Objectives: Stage IV small cell lung cancer (SCLC) is associated with short survival and progression after first-line systemic therapy frequently occurs within months. Although topotecan is approved for second-line treatment, its efficacy is limited, and treatment heterogeneity exists.Material and methods: The decision-making patterns for second line treatment of 13 European medical oncologists with expertise in SCLC were analyzed.Results: The two criteria most relevant to decision-making were the performance status and the interval of recurrence since first-line treatment.With an interval of less than 3 months since the end of first-line chemotherapy, 62 % of the experts recommended cyclophosphamide, doxorubicin and vincristine (CAV) for fit patients and 54 % recommended topotecan for unfit patients. For an interval of more than 6 months, a clear consensus for a re-challenge with a platinum doublet was achieved (92 %). However, there was no consensus on the second-line therapy with an interval of 3-6 months since the end of first-line therapy.Conclusion: Real world practice may differ from recommendations in general guidelines and cannot always be directly derived from trial results as other factor such as habits, patient's preference, convenience or costs have to be factored in.",
keywords = "Small cell lung cancer (SCLC), Second-line chemotherapy, Decision making, Objective consensus, OPEN-LABEL, PHASE-III, TOPOTECAN, CHEMOTHERAPY, MULTICENTER, RECHALLENGE, ETOPOSIDE, SELECTION, OUTCOMES, IASLC",
author = "M. Frueh and Panje, {C. M.} and M. Reck and F. Blackhall and R. Califano and F. Cappuzzo and B. Besse and S. Novello and P. Garrido and E. Felip and M. O'Brien and Ares, {L. Paz} and {de Marinis}, F. and Virginie Westeel and {De Ruysscher}, D. and Putora, {P. M.}",
note = "Funding Information: EF reports personal fees from Abbvie, AstraZeneca, Blue Print Medicines, Boehringer Ingelheim, BMS, Eli Lilly, Guardant Health, Jannsen, Medscape, Merck KGaA, Merck Sharp & Dohme, Novartis, Pfizer, Prime Oncology, Roche, Samsung, Takeda, Touchtime, GSK, Bayer; grants from Grant for Oncology Innovation (GOI), Fundacion Merck Salud, outside the submitted work; and Grifols: Independent Member of the Board. Funding Information: BB reports institutional grants from Abbvie, Amgen, AstraZeneca, BeiGene, Blueprint Medicines, BMS, Boehringer Ingelheim, Celgene, Cristal Therapeutics, Daiichi-Sankyo, Eli Lilly, GSK, Ignyta, IPSEN, Inivata, Janssen, Merck KGaA, MSD, Nektar, Onxeo, OSE immunotherapeutics, Pfizer, Pharma Mar, Roche-Genentech, Sanofi, Servier, Spectrum Pharmaceuticals, Takeda, Tiziana Pharma, Tolero Pharmaceuticals. Funding Information: MF reports advisor fees (paid to institution) from BMS, MSD, AstraZeneca, Boehringer Ingelheim, Roche, Takeda and institutional research grants from BMS and AstraZeneca Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = aug,
doi = "10.1016/j.lungcan.2020.03.024",
language = "English",
volume = "146",
pages = "6--11",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
}