TY - JOUR
T1 - Chitooligosaccharides for wound healing biomaterials engineering
AU - Jafari, Hafez
AU - Bernaerts, Katrien
AU - Dodi, Gianina
AU - Shavandi, Amin
N1 - Funding Information:
H.J and A.S. acknowledge funding from Innoviris Brussels , Belgium ( https://innoviris.brussels ) under the project 2019 – BRIDGE – 4: RE4BRU. The content is solely the responsibility of the authors and does not necessarily represent the official views of the above-mentioned funding agency. Input from Dr. David Cannella is greatly appreciated.
Funding Information:
H.J and A.S. acknowledge funding from Innoviris Brussels, Belgium (https://innoviris.brussels) under the project 2019 ? BRIDGE ? 4: RE4BRU. The content is solely the responsibility of the authors and does not necessarily represent the official views of the above-mentioned funding agency. Input from Dr. David Cannella is greatly appreciated.
Publisher Copyright:
© 2020
PY - 2020/12
Y1 - 2020/12
N2 - Chitooligosaccharides (CHOS) are oligomers of beta-(1-4) linked N-acetylglucosamine and D-glucosamine that are produced from chitin or chitosan using different enzymatic or chemical methods. CHOS are water-soluble and non-cytotoxic with diverse bioactivities such as antibacterial, anti-inflammation, anti-obesity, anti-tumor and antioxidant. These biological features make CHOS promising compounds for several medical and food applications. In this review, we critically summarize the biological activities of CHOS in biomaterials engineering with a particular focus on CHOS applications for skin tissue healing and regeneration. We also present an updated overview of CHOS fabrications into wound dressing biomaterials for several in vitro and in vivo studies.
AB - Chitooligosaccharides (CHOS) are oligomers of beta-(1-4) linked N-acetylglucosamine and D-glucosamine that are produced from chitin or chitosan using different enzymatic or chemical methods. CHOS are water-soluble and non-cytotoxic with diverse bioactivities such as antibacterial, anti-inflammation, anti-obesity, anti-tumor and antioxidant. These biological features make CHOS promising compounds for several medical and food applications. In this review, we critically summarize the biological activities of CHOS in biomaterials engineering with a particular focus on CHOS applications for skin tissue healing and regeneration. We also present an updated overview of CHOS fabrications into wound dressing biomaterials for several in vitro and in vivo studies.
KW - Chitooligosaccharide
KW - Physicochemical properties
KW - Antibacterial and antifungal
KW - Antioxidant
KW - Anti-inflammatory
KW - Immunostimulatory
KW - Wound healing
KW - in vitro and in vivo studies
KW - RADICAL SCAVENGING ACTIVITY
KW - OXIDIZED CHITOSAN OLIGOSACCHARIDE
KW - MOLECULAR-WEIGHT CHITOSANS
KW - WATER-SOLUBLE CHITOSAN
KW - BIOLOGICAL-ACTIVITIES
KW - ANTIBACTERIAL ACTIVITY
KW - ANTIOXIDANT ACTIVITY
KW - OXIDATIVE STRESS
KW - NITRIC-OXIDE
KW - PHYSICOCHEMICAL CHARACTERISTICS
U2 - 10.1016/j.msec.2020.111266
DO - 10.1016/j.msec.2020.111266
M3 - (Systematic) Review article
C2 - 32919632
SN - 0928-4931
VL - 117
JO - Materials Science & Engineering C-Materials for Biological Applications
JF - Materials Science & Engineering C-Materials for Biological Applications
M1 - 111266
ER -