Chitooligosaccharides for wound healing biomaterials engineering

Hafez Jafari, Katrien Bernaerts, Gianina Dodi, Amin Shavandi*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Chitooligosaccharides (CHOS) are oligomers of beta-(1-4) linked N-acetylglucosamine and D-glucosamine that are produced from chitin or chitosan using different enzymatic or chemical methods. CHOS are water-soluble and non-cytotoxic with diverse bioactivities such as antibacterial, anti-inflammation, anti-obesity, anti-tumor and antioxidant. These biological features make CHOS promising compounds for several medical and food applications. In this review, we critically summarize the biological activities of CHOS in biomaterials engineering with a particular focus on CHOS applications for skin tissue healing and regeneration. We also present an updated overview of CHOS fabrications into wound dressing biomaterials for several in vitro and in vivo studies.

Original languageEnglish
Article number111266
Number of pages17
JournalMaterials Science & Engineering C-Materials for Biological Applications
Volume117
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Chitooligosaccharide
  • Physicochemical properties
  • Antibacterial and antifungal
  • Antioxidant
  • Anti-inflammatory
  • Immunostimulatory
  • Wound healing
  • in vitro and in vivo studies
  • RADICAL SCAVENGING ACTIVITY
  • OXIDIZED CHITOSAN OLIGOSACCHARIDE
  • MOLECULAR-WEIGHT CHITOSANS
  • WATER-SOLUBLE CHITOSAN
  • BIOLOGICAL-ACTIVITIES
  • ANTIBACTERIAL ACTIVITY
  • ANTIOXIDANT ACTIVITY
  • OXIDATIVE STRESS
  • NITRIC-OXIDE
  • PHYSICOCHEMICAL CHARACTERISTICS

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