TY - JOUR
T1 - Childhood adversities and psychotic symptoms
T2 - The potential mediating or moderating role of neurocognition and social cognition
AU - Mansueto, Giovanni
AU - Schruers, Koen
AU - Cosci, Fiammetta
AU - van Os, Jim
AU - Alizadeh, Behrooz Z.
AU - Bartels-Velthuis, Agna A.
AU - van Beveren, Nico J.
AU - Bruggeman, Richard
AU - Cahn, Wiepke
AU - de Haan, Lieuwe
AU - Delespaul, Philippe
AU - Meijer, Carin J.
AU - Myin-Germeys, Inez
AU - Kahn, Rene S.
AU - Schirmbeck, Frederike
AU - Simons, Claudia J. P.
AU - van Haren, Neeltje E. M.
AU - van Winkel, Ruud
N1 - Funding Information:
The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (ZonMw, grant number 10-000-1001), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organizations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical center The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGZ Eindhoven en De Kempen, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta.)
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/4
Y1 - 2019/4
N2 - Introduction: Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglect on the one hand, and psychotic symptoms on the other.Method: The sampling frame was 1.119 patients with a psychotic disorder. Childhood adversity was evaluated with the Dutch version of the Childhood Trauma Questionnaire. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Verbal learning-memory, attention-vigilance, working memory, information processing speed, reasoning-problem solving were evaluated as measures of neurocognition using the Word Learning Task, the Continuous Performance Test, the Wechsler Adult Intelligence Scale 3rd. Mentalization was evaluated as a measure of social cognition using the Hinting Task. Correlation, mediation, moderation, 95% Bias Corrected and accelerated (BCaCI) bootstrapped analyses were performed, considering possible sex differences.Results: In male psychotic patients, attention and vigilance mediated the association between childhood neglect and negative symptoms (indirect effect: 0.18, BCaCI: 0.03-0.54), disorganization (indirect effect: 026, BCaCI: 0.05-0.61), excitement (indirect effect: 0.07, BCaCI: 0.004-0.23); mentalization mediated the association between childhood neglect and negative symptoms (indirect effect: 021. BCaCI: 0.02-051), excitement (indirect effect: 0.07, BCaCI: 0.01-0.20) disorganization (indirect effect: 0.29. BCaCI: 0.02-0.64); working memory mediated the association between childhood abuse and disorganization (indirect effect: 028, BCaCI: 0.05-0.57), excitement (indirect effect: 0.08, BCaCI: 0.01-020), emotional distress (indirect effect: 0.10, BCaCI: 0.01-027).Discussion: In psychotic disorder, sex-specific mediation of neurocognition and mentalization may exist in the association between childhood adversity and psychotic symptoms. (C) 2018 Elsevier B.V. All rights reserved.
AB - Introduction: Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglect on the one hand, and psychotic symptoms on the other.Method: The sampling frame was 1.119 patients with a psychotic disorder. Childhood adversity was evaluated with the Dutch version of the Childhood Trauma Questionnaire. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Verbal learning-memory, attention-vigilance, working memory, information processing speed, reasoning-problem solving were evaluated as measures of neurocognition using the Word Learning Task, the Continuous Performance Test, the Wechsler Adult Intelligence Scale 3rd. Mentalization was evaluated as a measure of social cognition using the Hinting Task. Correlation, mediation, moderation, 95% Bias Corrected and accelerated (BCaCI) bootstrapped analyses were performed, considering possible sex differences.Results: In male psychotic patients, attention and vigilance mediated the association between childhood neglect and negative symptoms (indirect effect: 0.18, BCaCI: 0.03-0.54), disorganization (indirect effect: 026, BCaCI: 0.05-0.61), excitement (indirect effect: 0.07, BCaCI: 0.004-0.23); mentalization mediated the association between childhood neglect and negative symptoms (indirect effect: 021. BCaCI: 0.02-051), excitement (indirect effect: 0.07, BCaCI: 0.01-0.20) disorganization (indirect effect: 0.29. BCaCI: 0.02-0.64); working memory mediated the association between childhood abuse and disorganization (indirect effect: 028, BCaCI: 0.05-0.57), excitement (indirect effect: 0.08, BCaCI: 0.01-020), emotional distress (indirect effect: 0.10, BCaCI: 0.01-027).Discussion: In psychotic disorder, sex-specific mediation of neurocognition and mentalization may exist in the association between childhood adversity and psychotic symptoms. (C) 2018 Elsevier B.V. All rights reserved.
KW - Childhood abuse
KW - Childhood neglect
KW - Social cognition
KW - Neurocognition
KW - NEGATIVE SYNDROME SCALE
KW - CANNABIS USE
KW - PSYCHOMETRIC PROPERTIES
KW - EXECUTIVE FUNCTION
KW - GENDER-DIFFERENCES
KW - HIGH-RISK
KW - TRAUMA
KW - SCHIZOPHRENIA
KW - ABUSE
KW - MIND
U2 - 10.1016/j.schres.2018.11.028
DO - 10.1016/j.schres.2018.11.028
M3 - Article
SN - 0920-9964
VL - 206
SP - 183
EP - 193
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -