Chemotherapy dose-intensification in breast cancer : is more better?

Research output: ThesisDoctoral ThesisInternal

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Abstract

With dose-intensification the quantity of administered chemotherapy is increased per time unit to achieve the best possible anti-tumour effect. This dissertation describes three methods of dose-intensification in breast cancer patients: 1/ standard dosage of chemotherapy where the cure interval is shortened (densification), 2/ standard cure interval where the dosage of the chemotherapy is increased (dose-escalation) and 3/ high dose chemotherapy with autologous (own) bone marrow transplantation (AuBMT). Compared to dose-escalation, densification results in a higher dose-intensity, a shorter total duration of treatment, a more favourable side-effect profile, a lower total dose of chemotherapy, and an equivalent anti-tumour effect. The results of high dose chemotherapy with AuBMT were disappointing. A study into the use of bone marrow transplantation (of sister or brother) as an anti-tumour treatment of metastasized breast cancer shows that this technique is applicable, but the effectiveness is for now limited.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Tjan - Heijnen, Vivianne, Supervisor
  • Schouten, Hendricus, Supervisor
Award date11 Jun 2010
Place of PublicationMaastricht
Publisher
Print ISBNs9789052789408
Publication statusPublished - 1 Jan 2010

Keywords

  • chemotherapy
  • dose-intensification
  • breast cancer

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