@article{cee51a268d4d41109258b57d8da3fbf8,
title = "Chemotherapy and vitamin D supplement use are determinants of serum 25-hydroxyvitamin D levels during the first six months after colorectal cancer diagnosis",
abstract = "Vitamin D metabolites, including 25-hydroxyvitamin D-3 (25(OH)D-3), may inhibit colorectal cancer (CRC) progression. Here we investigated cross-sectional and longitudinal associations of demographic, lifestyle and clinical characteristics with 25(OH)D-3 serum concentrations in CRC patients at diagnosis and six months later. In 1201 newly-diagnosed stage I-III CRC patients, 25(OH)D-3 levels were analysed twice. Multivariable linear regression was used to assess demographic, lifestyle and clinical determinants of 25(OH)D-3 levels at diagnosis and six months later. Linear mixed models were used to assess characteristics associated with changes in 25(OH)D-3 levels over time.Results of our study showed that vitamin D intake from diet or supplements, use of calcium supplements, BMI and disease stage were associated with 25(OH)D-3 levels at both time points. Six months after diagnosis, gender and having received chemo- and/or radiotherapy were also associated with 25(OH)D-3 levels. A stronger decrease in 25(OH)D-3 levels was observed in patients who underwent chemotherapy, compared to surgery only (beta-6.9 nmol/L 95 %CI -9.8; -4.0). Levels of 25(OH)D-3 levels increased in patients using vitamin D supplements compared to non-users (beta 4.0 nmol/L 95 %CI 1.2; 6.8).In conclusion, vitamin D supplement use and treatment appear to be important determinants of 25(OH)D3 levels during the first six months after CRC diagnosis, although the difference in 25(OH)D3 levels was minor.",
keywords = "serum 25(OH)D-3, Vitamin D, Colorectal cancer, Patients, Changes over time, Lifestyle and clinical determinants, QUALITY-OF-LIFE, D DEFICIENCY, SURVIVAL, STYLE, POPULATION, MORTALITY, HEALTH, SUN",
author = "Evertine Wesselink and Bours, {Martijn J. L.} and {de Wilt}, {Johannes H. W.} and Michiel Aquarius and Breukink, {Stephanie O.} and Bibi Hansson and Keulen, {Eric T. P.} and Kok, {Dieuwertje E.} and {van den Ouweland}, Jody and {van Roekel}, {Eline H.} and Merel Snellen and Renate Winkels and Witkamp, {Renger F.} and {van Zutphen}, Moniek and Weijenberg, {Matty P.} and Ellen Kampman and {van Duijnhoven}, {Franzel J. B.}",
note = "Funding Information: All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All patients signed informed consent and the COLON study was approved by the Committee on Research involving Human Subjects, region Arnhem-Nijmegen, the Netherlands (2009-349). The EnCoRe study was approved by the Medical Ethics Committee of the University Hospital Maastricht and Maastricht University, the Netherlands. Funding Information: The COLON study was financially supported by W ereld Kanker Onderzoek Fonds (WKOF) & W orld Cancer Research Fund International (WCRF International) as well as by funds from grant 2014/1179 as part of the W orld Cancer Research Fund International Regular Grant Programme ; A lpe d{\textquoteright}Huzes/Dutch Cancer Society ( UM 2012–5653, UW 2013–5927, UW 2015–7946); and E RA-NET on Translational Cancer Research (TRANSCAN/Dutch Cancer Society : UW2013-6397, UW2014-6877 and the N etherlands Organization for Health Research and Development (ZonMw, the Netherlands). The EnCoRe study was supported by grants from the S tichting Alpe d{\textquoteright}HuZes within the research program {\textquoteleft}Leven met kanker{\textquoteright} of the Dutch Cancer Society (Grant No. UM-2010-4867 and UM 2012–5653) and by a grant from K ankeronderzoekfonds Limburg as part of Health Foundation Limburg (Grant No. 00,005,739) . Eline H. van Roekel was funded by the W ereld Kanker Onderzoek Fonds (WKOF), part of the World Cancer Research Fund International grant programme (grant number 2016/1620) . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = may,
doi = "10.1016/j.jsbmb.2020.105577",
language = "English",
volume = "199",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
issn = "0960-0760",
publisher = "Elsevier Ltd",
}