Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

Marike W. van Gisbergen, Marcus Cebula*, Jie Zhang, Astrid Ottosson-Wadlund, Ludwig Dubois, Philippe Lambin, Kenneth D. Tew, Danyelle M. Townsend, Guido R. M. M. Haenen, Marie Jose Drittij - Reijnders, Hisao Saneyoshi, Mika Araki, Yuko Shishido, Yoshihiro Ito, Elias S. J. Arner, Hiroshi Abe, Ralf Morgenstern, Katarina Johansson*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Original languageEnglish
Pages (from-to)2010-2025
JournalMolecular Pharmaceutics
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2016

Keywords

  • glutathione transferases
  • prodrugs
  • MGST1
  • GSTA1
  • doxorubicin
  • etoposide
  • redox
  • TrxR1

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