Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

Marike W. van Gisbergen; Marcus Cebula; Jie Zhang; Astrid Ottosson-Wadlund; Ludwig Dubois; Philippe Lambin; Kenneth D. Tew; Danyelle M. Townsend; Guido R. M. M. Haenen; Marie Jose Drittij - Reijnders; Hisao Saneyoshi; Mika Araki; Yuko Shishido; Yoshihiro Ito; Elias S. J. Arner; Hiroshi Abe; Ralf Morgenstern; Katarina Johansson

doi:10.1021/acs.molpharmaceut.6b00140

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

Marike W. van Gisbergen, Marcus Cebula^*, Jie Zhang, Astrid Ottosson-Wadlund, Ludwig Dubois, Philippe Lambin, Kenneth D. Tew, Danyelle M. Townsend, Guido R. M. M. Haenen, Marie Jose Drittij - Reijnders, Hisao Saneyoshi, Mika Araki, Yuko Shishido, Yoshihiro Ito, Elias S. J. Arner, Hiroshi Abe, Ralf Morgenstern, Katarina Johansson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	2010-2025
Journal	Molecular Pharmaceutics
Volume	13
Issue number	6
DOIs	https://doi.org/10.1021/acs.molpharmaceut.6b00140
Publication status	Published - Jun 2016

Keywords

glutathione transferases
prodrugs
MGST1
GSTA1
doxorubicin
etoposide
redox
TrxR1

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10.1021/acs.molpharmaceut.6b00140

Full TextFinal published version, 6.11 MBLicence: Taverne

Cite this

van Gisbergen, M. W., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., Tew, K. D., Townsend, D. M., Haenen, G. R. M. M., Drittij - Reijnders, M. J., Saneyoshi, H., Araki, M., Shishido, Y., Ito, Y., Arner, E. S. J., Abe, H., Morgenstern, R., & Johansson, K. (2016). Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. Molecular Pharmaceutics, 13(6), 2010-2025. https://doi.org/10.1021/acs.molpharmaceut.6b00140

van Gisbergen, Marike W. ; Cebula, Marcus ; Zhang, Jie ; Ottosson-Wadlund, Astrid ; Dubois, Ludwig ; Lambin, Philippe ; Tew, Kenneth D. ; Townsend, Danyelle M. ; Haenen, Guido R. M. M. ; Drittij - Reijnders, Marie Jose ; Saneyoshi, Hisao ; Araki, Mika ; Shishido, Yuko ; Ito, Yoshihiro ; Arner, Elias S. J. ; Abe, Hiroshi ; Morgenstern, Ralf ; Johansson, Katarina. / Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. In: Molecular Pharmaceutics. 2016 ; Vol. 13, No. 6. pp. 2010-2025.

@article{0079af678c39426285faddbd005aa880,

title = "Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells",

keywords = "glutathione transferases, prodrugs, MGST1, GSTA1, doxorubicin, etoposide, redox, TrxR1",

author = "{van Gisbergen}, {Marike W.} and Marcus Cebula and Jie Zhang and Astrid Ottosson-Wadlund and Ludwig Dubois and Philippe Lambin and Tew, {Kenneth D.} and Townsend, {Danyelle M.} and Haenen, {Guido R. M. M.} and {Drittij - Reijnders}, {Marie Jose} and Hisao Saneyoshi and Mika Araki and Yuko Shishido and Yoshihiro Ito and Arner, {Elias S. J.} and Hiroshi Abe and Ralf Morgenstern and Katarina Johansson",

year = "2016",

month = jun,

doi = "10.1021/acs.molpharmaceut.6b00140",

language = "English",

volume = "13",

pages = "2010--2025",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

publisher = "American Chemical Society",

number = "6",

}

van Gisbergen, MW, Cebula, M, Zhang, J, Ottosson-Wadlund, A, Dubois, L , Lambin, P, Tew, KD, Townsend, DM, Haenen, GRMM , Drittij - Reijnders, MJ, Saneyoshi, H, Araki, M, Shishido, Y, Ito, Y, Arner, ESJ, Abe, H, Morgenstern, R & Johansson, K 2016, 'Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells', Molecular Pharmaceutics, vol. 13, no. 6, pp. 2010-2025. https://doi.org/10.1021/acs.molpharmaceut.6b00140

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. / van Gisbergen, Marike W.; Cebula, Marcus; Zhang, Jie; Ottosson-Wadlund, Astrid; Dubois, Ludwig ; Lambin, Philippe; Tew, Kenneth D.; Townsend, Danyelle M.; Haenen, Guido R. M. M.; Drittij - Reijnders, Marie Jose; Saneyoshi, Hisao; Araki, Mika; Shishido, Yuko; Ito, Yoshihiro; Arner, Elias S. J.; Abe, Hiroshi; Morgenstern, Ralf; Johansson, Katarina.

In: Molecular Pharmaceutics, Vol. 13, No. 6, 06.2016, p. 2010-2025.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

AU - van Gisbergen, Marike W.

AU - Cebula, Marcus

AU - Zhang, Jie

AU - Ottosson-Wadlund, Astrid

AU - Dubois, Ludwig

AU - Lambin, Philippe

AU - Tew, Kenneth D.

AU - Townsend, Danyelle M.

AU - Haenen, Guido R. M. M.

AU - Drittij - Reijnders, Marie Jose

AU - Saneyoshi, Hisao

AU - Araki, Mika

AU - Shishido, Yuko

AU - Ito, Yoshihiro

AU - Arner, Elias S. J.

AU - Abe, Hiroshi

AU - Morgenstern, Ralf

AU - Johansson, Katarina

PY - 2016/6

Y1 - 2016/6

KW - glutathione transferases

KW - prodrugs

KW - MGST1

KW - GSTA1

KW - doxorubicin

KW - etoposide

KW - redox

KW - TrxR1

U2 - 10.1021/acs.molpharmaceut.6b00140

DO - 10.1021/acs.molpharmaceut.6b00140

M3 - Article

C2 - 27093577

VL - 13

SP - 2010

EP - 2025

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 6

ER -