TY - JOUR
T1 - Chemical functionalization strategies for poly(aspartic acid) towards crosslinking and processing capabilities
AU - De Grave, Lauren
AU - Bernaerts, Katrien V.
AU - Van Vlierberghe, Sandra
N1 - Funding Information:
Project ‘GREENER’ was financed within the Interreg V program Flanders-the Netherlands , a cross-border consortium with financial support of the European Fund for Regional Development with co-financing of the province East-Flanders and the Ministry of Economic Affairs and Climate (the Netherlands) .
Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/2/16
Y1 - 2024/2/16
N2 - Poly(aspartic acid) (PASP) hydrogels have gained significant attention in recent years due to their excellent biocompatibility, biodegradability and tunable swelling behavior. This comprehensive review presents an overview of past and current research efforts focusing on PASP hydrogels, their functionalization strategies, processing methods and applications. The chemical functionalization of PASP is addressed, highlighting the ability to tailor the functionalities of PASP for customization. Precise control over functional groups for crosslinking enables the preparation of PASP hydrogels that can respond to environmental triggers, rendering them valuable for applications including, yet not limited to, controlled drug release, tissue engineering and self-healing concrete. Furthermore, the processing methods employed to produce PASP in different forms, such as films, nanoparticles and fibers are described. Finally, the applications of PASP hydrogels are overviewed, highlighting their potential to help improving human health and environmental sustainability by providing an alternative for fossil-based hydrogels.
AB - Poly(aspartic acid) (PASP) hydrogels have gained significant attention in recent years due to their excellent biocompatibility, biodegradability and tunable swelling behavior. This comprehensive review presents an overview of past and current research efforts focusing on PASP hydrogels, their functionalization strategies, processing methods and applications. The chemical functionalization of PASP is addressed, highlighting the ability to tailor the functionalities of PASP for customization. Precise control over functional groups for crosslinking enables the preparation of PASP hydrogels that can respond to environmental triggers, rendering them valuable for applications including, yet not limited to, controlled drug release, tissue engineering and self-healing concrete. Furthermore, the processing methods employed to produce PASP in different forms, such as films, nanoparticles and fibers are described. Finally, the applications of PASP hydrogels are overviewed, highlighting their potential to help improving human health and environmental sustainability by providing an alternative for fossil-based hydrogels.
KW - Biodegradable
KW - Biomaterial
KW - Crosslinking
KW - Hydrogels
KW - Poly(aspartic acid)
KW - Processing
U2 - 10.1016/j.polymer.2024.126723
DO - 10.1016/j.polymer.2024.126723
M3 - (Systematic) Review article
SN - 0032-3861
VL - 294
JO - Polymer
JF - Polymer
M1 - 126723
ER -