Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus

Dursun Aygun; Umit Akin Dere; Onur Yildiz; Yasin Temel; Ersoy Kocabicak

doi:10.5137/1019-5149.JTN.24348-18.3

Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus

Dursun Aygun, Umit Akin Dere^*, Onur Yildiz, Yasin Temel, Ersoy Kocabicak

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.

MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.

RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p 0.05).

CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.

Original language	English
Pages (from-to)	430-433
Number of pages	4
Journal	Turkish Neurosurgery
Volume	29
Issue number	3
DOIs	https://doi.org/10.5137/1019-5149.JTN.24348-18.3
Publication status	Published - 2019

Keywords

Parkinson's disease
Subthalamic nucleus
Deep brain stimulation
Microelectrode recording
Microlesion effect

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10.5137/1019-5149.JTN.24348-18.3

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@article{b80d2dd942d643569b1dde9d5d017269,

title = "Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus",

abstract = "AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.RESULTS: MLE scores improved by 21.7\% [left (L) side] and by 13.6\% [right (R) side] from baseline (p 0.05).CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.",

keywords = "Parkinson's disease, Subthalamic nucleus, Deep brain stimulation, Microelectrode recording, Microlesion effect",

author = "Dursun Aygun and Dere, \{Umit Akin\} and Onur Yildiz and Yasin Temel and Ersoy Kocabicak",

note = "Funding Information: Preparation for publication of this article is partly supported by Turkish Neurosurgical Society. Publisher Copyright: {\textcopyright} 2019 Turkish Neurosurgical Society.",

year = "2019",

doi = "10.5137/1019-5149.JTN.24348-18.3",

language = "English",

volume = "29",

pages = "430--433",

journal = "Turkish Neurosurgery",

issn = "1019-5149",

publisher = "Turkish Neurosurgical Society",

number = "3",

}

Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus. / Aygun, Dursun; Dere, Umit Akin; Yildiz, Onur et al.
In: Turkish Neurosurgery, Vol. 29, No. 3, 2019, p. 430-433.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus

AU - Aygun, Dursun

AU - Dere, Umit Akin

AU - Yildiz, Onur

AU - Temel, Yasin

AU - Kocabicak, Ersoy

PY - 2019

Y1 - 2019

N2 - AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p 0.05).CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.

AB - AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p 0.05).CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.

KW - Parkinson's disease

KW - Subthalamic nucleus

KW - Deep brain stimulation

KW - Microelectrode recording

KW - Microlesion effect

U2 - 10.5137/1019-5149.JTN.24348-18.3

DO - 10.5137/1019-5149.JTN.24348-18.3

M3 - Article

C2 - 30649828

SN - 1019-5149

VL - 29

SP - 430

EP - 433

JO - Turkish Neurosurgery

JF - Turkish Neurosurgery

IS - 3

ER -

Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus

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Keywords

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