Characteristics of subjective cognitive decline associated with amyloid positivity

O. Janssen*, W.J. Jansen, S.J.B. Vos, M. Boada, L. Parnetti, T. Gabryelewicz, T. Fladby, J.L. Molinuevo, S. Villeneuve, J. Hort, S. Epelbaum, A. Lleo, S. Engelborghs, W.M. van der Flier, S. Landau, J. Popp, A. Wallin, P. Scheltens, M.O. Rikkert, P.J. SnyderC. Rowe, G. Chetelat, A. Ruiz, M. Marquie, E. Chipi, S. Wolfsgruber, M. Heneka, H. Boecker, O. Peters, J. Jarholm, L. Rami, A. Tort-Merino, A.P. Binette, J. Poirier, P. Rosa-Neto, J. Cerman, B. Dubois, M. Teichmann, D. Alcolea, J. Fortea, M.B. Sanchez-Saudinos, J. Ebenau, C. Pocnet, M. Eckerstrom, L. Thompson, V. Villemagne, R. Buckley, S. Burnham, M. Delarue, Y. Freund-Levi, Alzheimer's Disease Neuroimaging Initiative, FACEHBI study group, PREVENT-AD research group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Original languageEnglish
Pages (from-to)1832 - 1845
Number of pages14
JournalAlzheimer's & Dementia
Early online date8 Dec 2021
Publication statusPublished - 2022


  • Alzheimer's disease
  • amyloid
  • cerebrospinal fluid
  • positron emission tomography
  • subjective cognitive decline
  • RISK

Cite this