Characteristics of screen-detected cancers following concordant or discordant recalls at blinded double reading in biennial digital screening mammography

Angela M. P. Coolen*, Joost R. C. Lameijer, Adri C. Voogd, Marieke W. J. Louwman, Luc J. Strobbe, Vivianne C. G. Tjan-Heijnen, Lucien E. M. Duijm

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

ObjectivesTo analyse which mammographic and tumour characteristics led to concordant versus discordant recalls at blinded double reading to further optimise our breast cancer screening programme.MethodsWe included a consecutive series of 99,013 screening mammograms obtained between July 2013 and January 2015. All mammograms were double read in a blinded fashion. Discordant readings were routinely recalled without consensus or arbitration. During the 2-year follow-up, relevant data of the recalled women were collected. We compared mammographic characteristics, screening outcome and tumour characteristics between concordant and discordant recalls.ResultsThere were 2,543 concordant recalls (71.4%) and 997 discordant recalls (28.0%). The positive predictive value of a concordant recall was significantly higher (23.5% vs. 10.0%, p <0.001). The proportion of BI-RADS 0 was significantly higher in the discordant recall group (75.7% vs. 56.3%, p <0.001). Discordant recalls were more often an asymmetry or architectural distortion (21.8% vs. 13.2% and 9.3% vs. 6.5%, respectively, p <0.001). There were no differences in the distribution of DCIS and invasive cancers and tumour characteristics were comparable for the two groups, except for a more favourable tumour grade in the discordant recall group (54.7% vs. 39.9% grade I tumours, p = 0.022).ConclusionsScreen-detected cancers detected by a discordant reading show a more favourable tumour grade than cancers diagnosed after a concordant recall. The higher proportion of asymmetries and architectural distortions in this group provide a possible target for improving screening programmes by additional training of screening radiologists and the implementation of digital breast tomosynthesis.Key Points center dot With blinded double reading of screening mammograms, screen-detected cancers detected by a discordant reading show a more favourable tumour grade than cancers diagnosed after a concordant recall.center dot The proportions of asymmetries and architectural distortions are higher in case of a discordant reading.center dot Possible improvement strategies could target additional training of screening radiologists and the implementation of digital breast tomosynthesis in breast cancer screening programmes.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalEuropean Radiology
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • Mass screening
  • Early detection of cancer
  • Breast neoplasms
  • Mammography
  • Follow-up studies
  • BREAST-CANCER
  • CLINICAL-EXPERIENCE
  • READER VARIABILITY
  • 3RD READER
  • TOMOSYNTHESIS
  • ARBITRATION
  • PROGRAM
  • SENSITIVITY
  • CATEGORIES

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