Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke

Ralph R. E. G. Geuskens; Jordi Borst; Marit Lucas; A. M. Merel Boers; Olvert A. Berkhemer; Yvo B. W. E. M. Roos; Marianne A. A. van Walderveen; Sjoerd F. M. Jenniskens; Wim H. van Zwam; Diederik W. J. Dippel; Charles B. L. M. Majoie; Henk A. Marquering

doi:10.1371/journal.pone.0141571

Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke

Ralph R. E. G. Geuskens^*
, Jordi Borst
, Marit Lucas
, A. M. Merel Boers
, Olvert A. Berkhemer
, Yvo B. W. E. M. Roos
, Marianne A. A. van Walderveen
, Sjoerd F. M. Jenniskens
, Wim H. van Zwam
, Diederik W. J. Dippel
, Charles B. L. M. Majoie
, Henk A. Marquering

^*Corresponding author for this work

DA BV Medisch Specialisten Radiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV

Original language	English
Article number	e0141571
Journal	PLOS ONE
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0141571
Publication status	Published - 4 Nov 2015

Access to Document

10.1371/journal.pone.0141571Licence: CC BY

Cite this

Geuskens, R. R. E. G., Borst, J., Lucas, M., Boers, A. M. M., Berkhemer, O. A., Roos, Y. B. W. E. M., van Walderveen, M. A. A., Jenniskens, S. F. M., van Zwam, W. H., Dippel, D. W. J., Majoie, C. B. L. M., & Marquering, H. A. (2015). Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke. PLOS ONE, 10(11), Article e0141571. https://doi.org/10.1371/journal.pone.0141571

@article{7aecedec00004cc6b300f5944d0ed415,

title = "Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke",

abstract = "Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145\%, aCBV",

author = "Geuskens, \{Ralph R. E. G.\} and Jordi Borst and Marit Lucas and Boers, \{A. M. Merel\} and Berkhemer, \{Olvert A.\} and Roos, \{Yvo B. W. E. M.\} and \{van Walderveen\}, \{Marianne A. A.\} and Jenniskens, \{Sjoerd F. M.\} and \{van Zwam\}, \{Wim H.\} and Dippel, \{Diederik W. J.\} and Majoie, \{Charles B. L. M.\} and Marquering, \{Henk A.\}",

year = "2015",

month = nov,

day = "4",

doi = "10.1371/journal.pone.0141571",

language = "English",

volume = "10",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "11",

}

TY - JOUR

T1 - Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke

AU - Geuskens, Ralph R. E. G.

AU - Borst, Jordi

AU - Lucas, Marit

AU - Boers, A. M. Merel

AU - Berkhemer, Olvert A.

AU - Roos, Yvo B. W. E. M.

AU - van Walderveen, Marianne A. A.

AU - Jenniskens, Sjoerd F. M.

AU - van Zwam, Wim H.

AU - Dippel, Diederik W. J.

AU - Majoie, Charles B. L. M.

AU - Marquering, Henk A.

PY - 2015/11/4

Y1 - 2015/11/4

N2 - Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV

AB - Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV

U2 - 10.1371/journal.pone.0141571

DO - 10.1371/journal.pone.0141571

M3 - Article

SN - 1932-6203

VL - 10

JO - PLOS ONE

JF - PLOS ONE

IS - 11

M1 - e0141571

ER -

Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke

Abstract

Access to Document

Fingerprint

Cite this