TY - JOUR
T1 - Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke
AU - Geuskens, Ralph R. E. G.
AU - Borst, Jordi
AU - Lucas, Marit
AU - Boers, A. M. Merel
AU - Berkhemer, Olvert A.
AU - Roos, Yvo B. W. E. M.
AU - van Walderveen, Marianne A. A.
AU - Jenniskens, Sjoerd F. M.
AU - van Zwam, Wim H.
AU - Dippel, Diederik W. J.
AU - Majoie, Charles B. L. M.
AU - Marquering, Henk A.
PY - 2015/11/4
Y1 - 2015/11/4
N2 - Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV
AB - Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV
U2 - 10.1371/journal.pone.0141571
DO - 10.1371/journal.pone.0141571
M3 - Article
SN - 1932-6203
VL - 10
JO - PLOS ONE
JF - PLOS ONE
IS - 11
M1 - e0141571
ER -