Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke

Ralph R. E. G. Geuskens*, Jordi Borst, Marit Lucas, A. M. Merel Boers, Olvert A. Berkhemer, Yvo B. W. E. M. Roos, Marianne A. A. van Walderveen, Sjoerd F. M. Jenniskens, Wim H. van Zwam, Diederik W. J. Dippel, Charles B. L. M. Majoie, Henk A. Marquering

*Corresponding author for this work

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Abstract

Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV
Original languageEnglish
Article numbere0141571
JournalPLOS ONE
Volume10
Issue number11
DOIs
Publication statusPublished - 4 Nov 2015

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