TY - JOUR
T1 - Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm
AU - Lodewijk, Lutske
AU - Kluijfhout, Wouter P.
AU - Kist, Jakob W.
AU - Stegeman, Inge
AU - Plukker, John T. M.
AU - van Dijkum, Els J. Nieveen
AU - Bonjer, H. Jaap
AU - Bouvy, Nicole D.
AU - Schepers, Abbey
AU - de Wilt, Johannes H. W.
AU - Netea-Maier, Romana T.
AU - van der Hage, Jos A.
AU - Burger, Jacobus W. A.
AU - Ho, Gavin
AU - Lee, Wayne S.
AU - Shen, Wen T.
AU - Aronova, Anna
AU - Zarnegar, Rasa
AU - Benay, Cassandre
AU - Mitmaker, Elliot J.
AU - Sywak, Mark S.
AU - Aniss, Ahmad M.
AU - Kruijff, Schelto
AU - James, Benjamin
AU - Grogan, Raymon H.
AU - Brunaud, Laurent
AU - Hoch, Guillaume
AU - Pandolfi, Chiara
AU - Ruan, Daniel T.
AU - Jones, Michael D.
AU - Guerrero, Marlon A.
AU - Valk, Gerlof D.
AU - Rinkes, Inne H. M. Borel
AU - Vriens, Menno R.
PY - 2016/5
Y1 - 2016/5
N2 - Purpose Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma. Results A total of 1313 patients were included, of whom 426 (32 %) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 %) papillary thyroid carcinomas (PTC), 124 (30 %) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 %) follicular thyroid carcinomas (FTC), and 3 (1 %) Hurthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 % were
AB - Purpose Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma. Results A total of 1313 patients were included, of whom 426 (32 %) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 %) papillary thyroid carcinomas (PTC), 124 (30 %) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 %) follicular thyroid carcinomas (FTC), and 3 (1 %) Hurthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 % were
KW - Differentiated thyroid carcinoma
KW - Contralateral carcinoma
KW - Papillary microcarcinoma
KW - Surgical strategy
U2 - 10.1007/s00423-016-1393-4
DO - 10.1007/s00423-016-1393-4
M3 - Article
C2 - 27013326
SN - 1435-2443
VL - 401
SP - 365
EP - 373
JO - Langenbeck's Archives of Surgery
JF - Langenbeck's Archives of Surgery
IS - 3
ER -