Chapter Two - Methodologies of Neuroepigenetic Research: Background, Challenges and Future Perspectives

Clara Snijders, Katherine C. Bassil, Laurence de Nijs*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

4 Citations (Web of Science)

Abstract

Over the last years, interest in epigenetic mechanisms has strongly increased in the field of neuroscience. Neuroepigenetics has intensely evolved and now refers to the assessment of a variety of epigenetic marks which can be found across several regions of the healthy or diseased brain. These marks include DNA (hydroxy) methylation, a large diversity of post-translational histone modifications and an increasing number of non-coding RNAs. The present chapter aims to concisely summarize the techniques used to study these mechanisms in the brain and provides an overview of their current challenges along with future perspectives that will allow the field to move forward.
Original languageEnglish
Title of host publicationNeuroepigenetics and Mental Illness
EditorsBart P.F. Rutten
Chapter2
Pages15-27
Number of pages13
Volume158
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

SeriesProgress in Molecular Biology and Translational Science
Volume158
ISSN1877-1173

Keywords

  • DYNAMIC DNA METHYLATION
  • MENDELIAN RANDOMIZATION
  • HISTONE MODIFICATIONS
  • 5-HYDROXYMETHYLCYTOSINE
  • 5-FORMYLCYTOSINE
  • EPIGENETICS
  • TOOL

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