Changes in transferrin are related to changes in insulin resistance: the SLIM study

C. Roumen; E.J.M. Feskens; E.H. Jansen; W.H. Saris; E.E. Blaak

doi:10.1111/j.1464-5491.2008.02589.x

Changes in transferrin are related to changes in insulin resistance: the SLIM study

C. Roumen^*, E.J.M. Feskens, E.H. Jansen, W.H. Saris, E.E. Blaak

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aims To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance. Methods Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance. Results After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance (P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2-h free fatty acids. Conclusions Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism. AD - Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, Maastricht, The Netherlands.

Original language	English
Pages (from-to)	1478-82
Journal	Diabetic Medicine
Volume	25
Issue number	12
DOIs	https://doi.org/10.1111/j.1464-5491.2008.02589.x
Publication status	Published - 1 Jan 2008

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10.1111/j.1464-5491.2008.02589.x

Cite this

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title = "Changes in transferrin are related to changes in insulin resistance: the SLIM study",

abstract = "Aims To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance. Methods Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance. Results After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance (P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2-h free fatty acids. Conclusions Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism. AD - Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, Maastricht, The Netherlands.",

author = "C. Roumen and E.J.M. Feskens and E.H. Jansen and W.H. Saris and E.E. Blaak",

year = "2008",

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TY - JOUR

T1 - Changes in transferrin are related to changes in insulin resistance: the SLIM study

AU - Roumen, C.

AU - Feskens, E.J.M.

AU - Jansen, E.H.

AU - Saris, W.H.

AU - Blaak, E.E.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Aims To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance. Methods Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance. Results After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance (P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2-h free fatty acids. Conclusions Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism. AD - Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, Maastricht, The Netherlands.

AB - Aims To determine the effect of a lifestyle intervention on serum transferrin and ferritin levels and the relationship between changes in transferrin and ferritin and changes in glucose tolerance and insulin resistance. Methods Randomized controlled lifestyle intervention directed at a healthy diet and increased physical activity in subjects with impaired glucose tolerance. Results After 1 year, the change in ferritin levels in the intervention group as compared with the control group did not reach statistical significance (P = 0.06). Transferrin change was independently related to the change in homeostasis model assessment of insulin resistance and ferritin change was related to the change in 2-h free fatty acids. Conclusions Changes in insulin sensitivity and postprandial lipid metabolism are related to changes in iron metabolism. AD - Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, Maastricht, The Netherlands.

U2 - 10.1111/j.1464-5491.2008.02589.x

DO - 10.1111/j.1464-5491.2008.02589.x

M3 - Article

C2 - 19046249

SN - 0742-3071

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SP - 1478

EP - 1482

JO - Diabetic Medicine

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