Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors

Lucy L Porter; Koen S Simons; Stijn Corsten; Brigitte Westerhof; Thijs C D Rettig; Esther Ewalds; Inge Janssen; Crétien Jacobs; Susanne van Santen; Arjen J C Slooter; Margaretha C E van der Woude; Johannes G van der Hoeven; Marieke Zegers; Mark van den Boogaard

doi:10.1186/s13054-024-05036-5

Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors

Lucy L Porter, Koen S Simons, Stijn Corsten, Brigitte Westerhof, Thijs C D Rettig, Esther Ewalds, Inge Janssen, Crétien Jacobs, Susanne van Santen, Arjen J C Slooter, Margaretha C E van der Woude, Johannes G van der Hoeven, Marieke Zegers, Mark van den Boogaard^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors. METHODS: Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of = 0.08. Subgroups of patients were based on admission diagnosis. RESULTS: A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL. CONCLUSIONS: This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care. TRIAL REGISTRATION: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.

Original language	English
Article number	255
Number of pages	9
Journal	Critical Care
Volume	28
Issue number	1
DOIs	https://doi.org/10.1186/s13054-024-05036-5
Publication status	Published - 25 Jul 2024

Keywords

Critical care outcomes
Patient-reported outcome measures
Prognosis
Quality of life
Humans
Quality of Life/psychology
Prospective Studies
Female
Male
Middle Aged
Survivors/psychology statistics & numerical data
Intensive Care Units/organization & administration statistics & numerical data
Aged
Surveys and Questionnaires
Cohort Studies
Adult
Critical Illness/psychology therapy
Critical Care/methods psychology

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Porter, L. L., Simons, K. S., Corsten, S., Westerhof, B., Rettig, T. C. D., Ewalds, E., Janssen, I., Jacobs, C., van Santen, S., Slooter, A. J. C., van der Woude, M. C. E., van der Hoeven, J. G., Zegers, M., & van den Boogaard, M. (2024). Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors. Critical Care, 28(1), Article 255. https://doi.org/10.1186/s13054-024-05036-5

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title = "Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors",

abstract = "BACKGROUND: With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors. METHODS: Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of = 0.08. Subgroups of patients were based on admission diagnosis. RESULTS: A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL. CONCLUSIONS: This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care. TRIAL REGISTRATION: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.",

keywords = "Critical care outcomes, Patient-reported outcome measures, Prognosis, Quality of life, Humans, Quality of Life/psychology, Prospective Studies, Female, Male, Middle Aged, Survivors/psychology statistics & numerical data, Intensive Care Units/organization & administration statistics & numerical data, Aged, Surveys and Questionnaires, Cohort Studies, Adult, Critical Illness/psychology therapy, Critical Care/methods psychology",

author = "Porter, {Lucy L} and Simons, {Koen S} and Stijn Corsten and Brigitte Westerhof and Rettig, {Thijs C D} and Esther Ewalds and Inge Janssen and Cr{\'e}tien Jacobs and {van Santen}, Susanne and Slooter, {Arjen J C} and {van der Woude}, {Margaretha C E} and {van der Hoeven}, {Johannes G} and Marieke Zegers and {van den Boogaard}, Mark",

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doi = "10.1186/s13054-024-05036-5",

language = "English",

volume = "28",

journal = "Critical Care",

issn = "1364-8535",

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number = "1",

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Porter, LL, Simons, KS, Corsten, S, Westerhof, B, Rettig, TCD, Ewalds, E, Janssen, I, Jacobs, C, van Santen, S, Slooter, AJC, van der Woude, MCE, van der Hoeven, JG, Zegers, M & van den Boogaard, M 2024, 'Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors', Critical Care, vol. 28, no. 1, 255. https://doi.org/10.1186/s13054-024-05036-5

TY - JOUR

T1 - Changes in quality of life 1 year after intensive care

T2 - a multicenter prospective cohort of ICU survivors

AU - Porter, Lucy L

AU - Simons, Koen S

AU - Corsten, Stijn

AU - Westerhof, Brigitte

AU - Rettig, Thijs C D

AU - Ewalds, Esther

AU - Janssen, Inge

AU - Jacobs, Crétien

AU - van Santen, Susanne

AU - Slooter, Arjen J C

AU - van der Woude, Margaretha C E

AU - van der Hoeven, Johannes G

AU - Zegers, Marieke

AU - van den Boogaard, Mark

PY - 2024/7/25

Y1 - 2024/7/25

N2 - BACKGROUND: With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors. METHODS: Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of = 0.08. Subgroups of patients were based on admission diagnosis. RESULTS: A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL. CONCLUSIONS: This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care. TRIAL REGISTRATION: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.

AB - BACKGROUND: With survival rates of critical illness increasing, quality of life measures are becoming an important outcome of ICU treatment. Therefore, to study the impact of critical illness on quality of life, we explored quality of life before and 1 year after ICU admission in different subgroups of ICU survivors. METHODS: Data from an ongoing prospective multicenter cohort study, the MONITOR-IC, were used. Patients admitted to the ICU in one of eleven participating hospitals between July 2016 and June 2021 were included. Outcome was defined as change in quality of life, measured using the EuroQol five-dimensional (EQ-5D-5L) questionnaire, and calculated by subtracting the EQ-5D-5L score 1 day before hospital admission from the EQ-5D-5L score 1 year post-ICU. Based on the minimal clinically important difference, a change in quality of life was defined as a change in EQ-5D-5L score of = 0.08. Subgroups of patients were based on admission diagnosis. RESULTS: A total of 3913 (50.6%) included patients completed both baseline and follow-up questionnaires. 1 year post-ICU, patients admitted after a cerebrovascular accident, intracerebral hemorrhage, or (neuro)trauma, on average experienced a significant decrease in quality of life. Conversely, 11 other subgroups of ICU survivors reported improvements in quality of life. The largest average increase in quality of life was seen in patients admitted due to respiratory disease (mean 0.17, SD 0.38), whereas the largest average decrease was observed in trauma patients (mean -0.13, SD 0.28). However, in each of the studied 22 subgroups there were survivors who reported a significant increase in QoL and survivors who reported a significant decrease in QoL. CONCLUSIONS: This large prospective multicenter cohort study demonstrated the diversity in long-term quality of life between, and even within, subgroups of ICU survivors. These findings emphasize the need for personalized information and post-ICU care. TRIAL REGISTRATION: The MONITOR-IC study was registered at ClinicalTrials.gov: NCT03246334 on August 2nd 2017.

KW - Critical care outcomes

KW - Patient-reported outcome measures

KW - Prognosis

KW - Quality of life

KW - Humans

KW - Quality of Life/psychology

KW - Prospective Studies

KW - Female

KW - Male

KW - Middle Aged

KW - Survivors/psychology statistics & numerical data

KW - Intensive Care Units/organization & administration statistics & numerical data

KW - Aged

KW - Surveys and Questionnaires

KW - Cohort Studies

KW - Adult

KW - Critical Illness/psychology therapy

KW - Critical Care/methods psychology

U2 - 10.1186/s13054-024-05036-5

DO - 10.1186/s13054-024-05036-5

M3 - Article

SN - 1364-8535

VL - 28

JO - Critical Care

JF - Critical Care

IS - 1

M1 - 255

ER -

Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors

Abstract

Keywords

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