Changes in Cardiac Metabolism in Prediabetes

V.H.W. de Wit-Verheggen, T. van de Weijer*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac function that precedes the onset of cardiac failure, and it occurs already in the prediabetic state. It is clear that these changes are closely linked to alterations in cardiac metabolism; however, the exact etiology is unknown. In this narrative review, we provide an overview of the early cardiac changes in fatty acid and glucose metabolism in prediabetes and its consequences on cardiac function. A better understanding of the relationship between metabolism, mitochondrial function, and cardiac function will lead to insights into the etiology of the declined cardiac function in prediabetes.
Original languageEnglish
Article number1680
Number of pages14
JournalBiomolecules
Volume11
Issue number11
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • cardiac metabolism
  • prediabetes
  • mitochondrial function
  • cardiac function
  • EPICARDIAL ADIPOSE-TISSUE
  • CORONARY-ARTERY-DISEASE
  • DIABETIC CARDIOMYOPATHY
  • DIASTOLIC DYSFUNCTION
  • INSULIN-RESISTANCE
  • HEART-DISEASE
  • PPAR-ALPHA
  • MYOCARDIAL TRIGLYCERIDES
  • MAGNETIC-RESONANCE
  • PERICARDIAL FAT

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