Abstract
Background/Aims: To investigate whether short-term changes in body composition as a result of growth hormone therapy could be used to predict its growth effect after 1 year in children with growth hormone deficiency (GHD) and children born small for gestational age (SGA). Methods: 88 GHD children and 99 SGA children who started treatment with recombinant human growth hormone were included. Total body water (TBW) and height were measured. After 1 year, patients were divided into adequate and inadequate responders. Results: In GHD and SGA children a sensitivity of 87 and 53%, respectively, and a specificity of 58 and 83%, respectively, were found. The positive predictive values for GHD and SGA children were 73 and 90%, respectively. The negative predictive values were 75 and 32%, respectively. Conclusion: Changes in body composition data measured by TBW are a valuable tool to correctly predict 75% of the GHD children and are only useful in SGA children when the change in TBW is above the cut-off value of 0.7 l/m(2).
Original language | English |
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Pages (from-to) | 18-23 |
Number of pages | 6 |
Journal | Hormone Research in Paediatrics |
Volume | 78 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2012 |
Keywords
- Body composition
- Growth hormone therapy
- Growth hormone deficiency
- Small for gestational age children
- FOR-GESTATIONAL-AGE
- BONE-MINERAL DENSITY
- ENERGY-EXPENDITURE
- SHORT CHILDREN
- GH DEFICIENCY
- THERAPY