Challenges to, and prospects for, reverse engineering the gastrointestinal tract using organoids

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

For over a decade, organoids mimicking the development, physiology, and disease of the digestive system have been a topic of broad interest and intense study. Establishing organoid models that recapitulate all distinct regions of the gastrointestinal tract (GIT) has proven challenging since each tissue surrogate requires tailor-made modifications of the original protocol to generate intestinal organoids. In this review, we discuss the challenges and current advances of the GIT organoid models. Moreover, we envision the next-generation GIT organoids as integrated organoid models, able to recapitulate structural and functional characteristics of multiple regions of the digestive tube in a single in vitro model. We discuss these new trends and provide an outlook for the future of GIT in vitro models.

Original languageEnglish
Pages (from-to)932-944
Number of pages13
JournalTrends in Biotechnology
Volume40
Issue number8
Early online date24 Feb 2022
DOIs
Publication statusPublished - Aug 2022

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