Challenges of clinical translation in nanomedicine: A qualitative study

Priya Satalkar*, Bernice Simon Elger, Patrick Hunziker, David Shaw

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Clinical translation of breakthroughs in nanotechnology and nanomedicine is expected to significantly improve diagnostic tools and therapeutic modalities for various diseases. This will not only improve human health and well-being, but is also likely to reduce health care costs in the long run. However, clinical translation is a long, arduous, resource intensive process that requires priority setting, resource mobilization, successful national and international collaboration, and effective coordination between key stakeholders. The aim of this paper is to describe various challenges faced by the stakeholders involved in translational nanomedicine while planning and conducting first in human clinical trials. We draw on insights obtained from 46 in-depth qualitative interviews with key stakeholders from Europe and North America.Translational research is a crucial step in bringing basic research into clinical reality. This is particularly important in a new field like nanomedicine. Clinical translation is a long and resource intensive process with difficulties along the way. In this article, the authors looked at the challenges faced by various parties in order to help identify ways to overcome these challenges.
Original languageEnglish
Pages (from-to)893-900
JournalNanomedicine-Nanotechnology Biology and Medicine
Issue number4
Publication statusPublished - May 2016


  • Translational research
  • Nanomedicine
  • First in human (FIH) trials
  • Challenges
  • Qualitative research

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