Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

K. A. P. Meeuwis; L. B. Hilbrands; J. IntHout; B. F. M. Slangen; I. M. P. Hendriks; F. Hinten; M. H. L. Christiaans; W. G. V. Quint; P. C. M. van de Kerkhof; L. F. A. G. Massuger; A. J. Hoitsma; M. M. van Rossum; W. J. G. Melchers; J. A. de Hullu

doi:10.1111/ajt.13053

Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

K. A. P. Meeuwis^*, L. B. Hilbrands, J. IntHout, B. F. M. Slangen, I. M. P. Hendriks, F. Hinten, M. H. L. Christiaans, W. G. V. Quint, P. C. M. van de Kerkhof, L. F. A. G. Massuger, A. J. Hoitsma, M. M. van Rossum, W. J. G. Melchers, J. A. de Hullu

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.

Original language	English
Pages (from-to)	723-733
Journal	American Journal of Transplantation
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/ajt.13053
Publication status	Published - Mar 2015

Keywords

Cancer
malignancy
neoplasia
clinical research
practice
infection and infectious agents
obstetrics and gynecology
viral: papillomavirus

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Meeuwis, K. A. P., Hilbrands, L. B., IntHout, J., Slangen, B. F. M., Hendriks, I. M. P., Hinten, F., Christiaans, M. H. L., Quint, W. G. V., van de Kerkhof, P. C. M., Massuger, L. F. A. G., Hoitsma, A. J., van Rossum, M. M., Melchers, W. J. G., & de Hullu, J. A. (2015). Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study. American Journal of Transplantation, 15(3), 723-733. https://doi.org/10.1111/ajt.13053

@article{06bdbe908017471dba88fb526469d422,

title = "Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study",

abstract = " Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.",

keywords = "Cancer, malignancy, neoplasia, clinical research, practice, infection and infectious agents, obstetrics and gynecology, viral: papillomavirus",

author = "Meeuwis, {K. A. P.} and Hilbrands, {L. B.} and J. IntHout and Slangen, {B. F. M.} and Hendriks, {I. M. P.} and F. Hinten and Christiaans, {M. H. L.} and Quint, {W. G. V.} and {van de Kerkhof}, {P. C. M.} and Massuger, {L. F. A. G.} and Hoitsma, {A. J.} and {van Rossum}, {M. M.} and Melchers, {W. J. G.} and {de Hullu}, {J. A.}",

year = "2015",

month = mar,

doi = "10.1111/ajt.13053",

language = "English",

volume = "15",

pages = "723--733",

journal = "American Journal of Transplantation",

issn = "1600-6135",

publisher = "Wiley",

number = "3",

}

Meeuwis, KAP, Hilbrands, LB, IntHout, J, Slangen, BFM, Hendriks, IMP, Hinten, F, Christiaans, MHL, Quint, WGV, van de Kerkhof, PCM, Massuger, LFAG, Hoitsma, AJ, van Rossum, MM, Melchers, WJG & de Hullu, JA 2015, 'Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study', American Journal of Transplantation, vol. 15, no. 3, pp. 723-733. https://doi.org/10.1111/ajt.13053

TY - JOUR

T1 - Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

AU - Meeuwis, K. A. P.

AU - Hilbrands, L. B.

AU - IntHout, J.

AU - Slangen, B. F. M.

AU - Hendriks, I. M. P.

AU - Hinten, F.

AU - Christiaans, M. H. L.

AU - Quint, W. G. V.

AU - van de Kerkhof, P. C. M.

AU - Massuger, L. F. A. G.

AU - Hoitsma, A. J.

AU - van Rossum, M. M.

AU - Melchers, W. J. G.

AU - de Hullu, J. A.

PY - 2015/3

Y1 - 2015/3

N2 - Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.

AB - Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.

KW - Cancer

KW - malignancy

KW - neoplasia

KW - clinical research

KW - practice

KW - infection and infectious agents

KW - obstetrics and gynecology

KW - viral: papillomavirus

U2 - 10.1111/ajt.13053

DO - 10.1111/ajt.13053

M3 - Article

C2 - 25675976

SN - 1600-6135

VL - 15

SP - 723

EP - 733

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 3

ER -

Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

Abstract

Keywords

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