Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

K. A. P. Meeuwis; L. B. Hilbrands; J. IntHout; B. F. M. Slangen; I. M. P. Hendriks; F. Hinten; M. H. L. Christiaans; W. G. V. Quint; P. C. M. van de Kerkhof; L. F. A. G. Massuger; A. J. Hoitsma; M. M. van Rossum; W. J. G. Melchers; J. A. de Hullu

doi:10.1111/ajt.13053

Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

K. A. P. Meeuwis^*, L. B. Hilbrands, J. IntHout, B. F. M. Slangen, I. M. P. Hendriks, F. Hinten, M. H. L. Christiaans, W. G. V. Quint, P. C. M. van de Kerkhof, L. F. A. G. Massuger, A. J. Hoitsma, M. M. van Rossum, W. J. G. Melchers, J. A. de Hullu

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.

Original language	English
Pages (from-to)	723-733
Journal	American Journal of Transplantation
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/ajt.13053
Publication status	Published - Mar 2015

Keywords

Cancer
malignancy
neoplasia
clinical research
practice
infection and infectious agents
obstetrics and gynecology
viral: papillomavirus

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10.1111/ajt.13053Licence: CC BY-NC-ND

Cite this

Meeuwis, K. A. P., Hilbrands, L. B., IntHout, J., Slangen, B. F. M., Hendriks, I. M. P., Hinten, F., Christiaans, M. H. L., Quint, W. G. V., van de Kerkhof, P. C. M., Massuger, L. F. A. G., Hoitsma, A. J., van Rossum, M. M., Melchers, W. J. G., & de Hullu, J. A. (2015). Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study. American Journal of Transplantation, 15(3), 723-733. https://doi.org/10.1111/ajt.13053

@article{06bdbe908017471dba88fb526469d422,

title = "Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study",

abstract = " Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.",

keywords = "Cancer, malignancy, neoplasia, clinical research, practice, infection and infectious agents, obstetrics and gynecology, viral: papillomavirus",

author = "Meeuwis, {K. A. P.} and Hilbrands, {L. B.} and J. IntHout and Slangen, {B. F. M.} and Hendriks, {I. M. P.} and F. Hinten and Christiaans, {M. H. L.} and Quint, {W. G. V.} and {van de Kerkhof}, {P. C. M.} and Massuger, {L. F. A. G.} and Hoitsma, {A. J.} and {van Rossum}, {M. M.} and Melchers, {W. J. G.} and {de Hullu}, {J. A.}",

year = "2015",

month = mar,

doi = "10.1111/ajt.13053",

language = "English",

volume = "15",

pages = "723--733",

journal = "American Journal of Transplantation",

issn = "1600-6135",

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Meeuwis, KAP, Hilbrands, LB, IntHout, J, Slangen, BFM, Hendriks, IMP, Hinten, F, Christiaans, MHL, Quint, WGV, van de Kerkhof, PCM, Massuger, LFAG, Hoitsma, AJ, van Rossum, MM, Melchers, WJG & de Hullu, JA 2015, 'Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study', American Journal of Transplantation, vol. 15, no. 3, pp. 723-733. https://doi.org/10.1111/ajt.13053

TY - JOUR

T1 - Cervicovaginal HPV Infection in Female Renal Transplant Recipients: An Observational, Self-Sampling Based, Cohort Study

AU - Meeuwis, K. A. P.

AU - Hilbrands, L. B.

AU - IntHout, J.

AU - Slangen, B. F. M.

AU - Hendriks, I. M. P.

AU - Hinten, F.

AU - Christiaans, M. H. L.

AU - Quint, W. G. V.

AU - van de Kerkhof, P. C. M.

AU - Massuger, L. F. A. G.

AU - Hoitsma, A. J.

AU - van Rossum, M. M.

AU - Melchers, W. J. G.

AU - de Hullu, J. A.

PY - 2015/3

Y1 - 2015/3

N2 - Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.

AB - Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital (pre)malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs was included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular. The studied cohort showed a broad range of HPV genotypes and multiple HPV genotypes were found in 27.1% of HPV-positive patients. Seven participants were identified with occult premalignant anogenital lesions. In conclusion, this study shows a high point-prevalence of HPV in female RTRs (age-matched West-European general population: 9-10%) with a shift in the distribution of genotypes as compared with the general population. Moreover, a substantial number of patients with occult premalignancies was identified. The introduction of self-sampling for HPV positivity can help in early detection of (pre)malignant anogenital lesions in this vulnerable population.

KW - Cancer

KW - malignancy

KW - neoplasia

KW - clinical research

KW - practice

KW - infection and infectious agents

KW - obstetrics and gynecology

KW - viral: papillomavirus

U2 - 10.1111/ajt.13053

DO - 10.1111/ajt.13053

M3 - Article

C2 - 25675976

SN - 1600-6135

VL - 15

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JO - American Journal of Transplantation

JF - American Journal of Transplantation

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