Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells

Rajendrarao Sumitha, Venkataswamy M. Manjunatha, Rajesh K. Sabitha, Phalguni A. Alladi, A. Nalini, Laxmi T. Rao, B. K. Chandrasekhar Sagar, Harry W. M. Steinbusch, Boris W. Kramer, T. N. Sathyaprabha, Trichur R. Raju*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1014-1034
Number of pages21
JournalMolecular Neurobiology
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Amyotrophic lateral sclerosis
  • Motor neurons
  • Human embryonic stem cells
  • Cerebrospinal fluid
  • TRANSGENIC MOUSE MODEL
  • MICROTUBULE-ASSOCIATED PROTEINS
  • CU,ZN SUPEROXIDE-DISMUTASE
  • BDNF MESSENGER-RNA
  • SPINAL-CORD
  • GOLGI-APPARATUS
  • CORTICAL HYPEREXCITABILITY
  • RESPIRATORY-CHAIN
  • ER STRESS
  • NEUROFILAMENT PHOSPHORYLATION

Cite this

Sumitha, Rajendrarao ; Manjunatha, Venkataswamy M. ; Sabitha, Rajesh K. ; Alladi, Phalguni A. ; Nalini, A. ; Rao, Laxmi T. ; Sagar, B. K. Chandrasekhar ; Steinbusch, Harry W. M. ; Kramer, Boris W. ; Sathyaprabha, T. N. ; Raju, Trichur R. / Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells. In: Molecular Neurobiology. 2019 ; Vol. 56, No. 2. pp. 1014-1034.
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title = "Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells",
keywords = "Amyotrophic lateral sclerosis, Motor neurons, Human embryonic stem cells, Cerebrospinal fluid, TRANSGENIC MOUSE MODEL, MICROTUBULE-ASSOCIATED PROTEINS, CU,ZN SUPEROXIDE-DISMUTASE, BDNF MESSENGER-RNA, SPINAL-CORD, GOLGI-APPARATUS, CORTICAL HYPEREXCITABILITY, RESPIRATORY-CHAIN, ER STRESS, NEUROFILAMENT PHOSPHORYLATION",
author = "Rajendrarao Sumitha and Manjunatha, {Venkataswamy M.} and Sabitha, {Rajesh K.} and Alladi, {Phalguni A.} and A. Nalini and Rao, {Laxmi T.} and Sagar, {B. K. Chandrasekhar} and Steinbusch, {Harry W. M.} and Kramer, {Boris W.} and Sathyaprabha, {T. N.} and Raju, {Trichur R.}",
year = "2019",
month = "2",
doi = "10.1007/s12035-018-1149-y",
language = "English",
volume = "56",
pages = "1014--1034",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Springer, Cham",
number = "2",

}

Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells. / Sumitha, Rajendrarao; Manjunatha, Venkataswamy M.; Sabitha, Rajesh K.; Alladi, Phalguni A.; Nalini, A.; Rao, Laxmi T.; Sagar, B. K. Chandrasekhar; Steinbusch, Harry W. M.; Kramer, Boris W.; Sathyaprabha, T. N.; Raju, Trichur R.

In: Molecular Neurobiology, Vol. 56, No. 2, 02.2019, p. 1014-1034.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells

AU - Sumitha, Rajendrarao

AU - Manjunatha, Venkataswamy M.

AU - Sabitha, Rajesh K.

AU - Alladi, Phalguni A.

AU - Nalini, A.

AU - Rao, Laxmi T.

AU - Sagar, B. K. Chandrasekhar

AU - Steinbusch, Harry W. M.

AU - Kramer, Boris W.

AU - Sathyaprabha, T. N.

AU - Raju, Trichur R.

PY - 2019/2

Y1 - 2019/2

KW - Amyotrophic lateral sclerosis

KW - Motor neurons

KW - Human embryonic stem cells

KW - Cerebrospinal fluid

KW - TRANSGENIC MOUSE MODEL

KW - MICROTUBULE-ASSOCIATED PROTEINS

KW - CU,ZN SUPEROXIDE-DISMUTASE

KW - BDNF MESSENGER-RNA

KW - SPINAL-CORD

KW - GOLGI-APPARATUS

KW - CORTICAL HYPEREXCITABILITY

KW - RESPIRATORY-CHAIN

KW - ER STRESS

KW - NEUROFILAMENT PHOSPHORYLATION

U2 - 10.1007/s12035-018-1149-y

DO - 10.1007/s12035-018-1149-y

M3 - Article

VL - 56

SP - 1014

EP - 1034

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 2

ER -