Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells

Rajendrarao Sumitha, Venkataswamy M. Manjunatha, Rajesh K. Sabitha, Phalguni A. Alladi, A. Nalini, Laxmi T. Rao, B. K. Chandrasekhar Sagar, Harry W. M. Steinbusch, Boris W. Kramer, T. N. Sathyaprabha, Trichur R. Raju*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1014-1034
Number of pages21
JournalMolecular Neurobiology
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Amyotrophic lateral sclerosis
  • Motor neurons
  • Human embryonic stem cells
  • Cerebrospinal fluid
  • TRANSGENIC MOUSE MODEL
  • MICROTUBULE-ASSOCIATED PROTEINS
  • CU,ZN SUPEROXIDE-DISMUTASE
  • BDNF MESSENGER-RNA
  • SPINAL-CORD
  • GOLGI-APPARATUS
  • CORTICAL HYPEREXCITABILITY
  • RESPIRATORY-CHAIN
  • ER STRESS
  • NEUROFILAMENT PHOSPHORYLATION

Cite this