TY - JOUR
T1 - Cerebral pathology and cognition in diabetes
T2 - the merits of multiparametric neuroimaging
AU - van Bussel, Frank C. G.
AU - Backes, Walter H.
AU - Hofman, Paul A. M.
AU - van Oostenbrugge, Robert J.
AU - van Boxtel, Martin P. J.
AU - Verhey, Frans R. J.
AU - Steinbusch, Harry W. M.
AU - Schram, Miranda T.
AU - Stehouwer, Coen D. A.
AU - Wildberger, Joachim E.
AU - Jansen, Jaap JFA
PY - 2017/4/5
Y1 - 2017/4/5
N2 - Type 2 diabetes mellitus is associated with accelerated cognitive decline and various cerebral abnormalities visible on MRI. The exact pathophysiological mechanisms underlying cognitive decline in diabetes still remain to be elucidated. In addition to conventional images, MRI offers a versatile set of novel contrasts, including blood perfusion, neuronal function, white matter microstructure, and metabolic function. These more-advanced multiparametric MRI contrasts and the pertaining parameters are able to reveal abnormalities in type 2 diabetes, which may be related to cognitive decline. To further elucidate the nature of the link between diabetes, cognitive decline, and brain abnormalities, and changes over time thereof, biomarkers are needed which can be provided by advanced MRI techniques. This review summarizes to what extent MRI, especially advanced multiparametric techniques, can elucidate the underlying neuronal substrate that reflects the cognitive decline in type 2 diabetes.
AB - Type 2 diabetes mellitus is associated with accelerated cognitive decline and various cerebral abnormalities visible on MRI. The exact pathophysiological mechanisms underlying cognitive decline in diabetes still remain to be elucidated. In addition to conventional images, MRI offers a versatile set of novel contrasts, including blood perfusion, neuronal function, white matter microstructure, and metabolic function. These more-advanced multiparametric MRI contrasts and the pertaining parameters are able to reveal abnormalities in type 2 diabetes, which may be related to cognitive decline. To further elucidate the nature of the link between diabetes, cognitive decline, and brain abnormalities, and changes over time thereof, biomarkers are needed which can be provided by advanced MRI techniques. This review summarizes to what extent MRI, especially advanced multiparametric techniques, can elucidate the underlying neuronal substrate that reflects the cognitive decline in type 2 diabetes.
KW - type 2 diabetes mellitus
KW - magnetic resonance imaging
KW - cognition
KW - functional MRI
KW - multiparametric MRI
U2 - 10.3389/fnins.2017.00188
DO - 10.3389/fnins.2017.00188
M3 - Article
C2 - 28424581
SN - 1662-453X
VL - 11
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
IS - APR
M1 - 188
ER -