Abstract

We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.

Original languageEnglish
Article number10
Number of pages9
JournalScientific Reports
Volume6
Issue number1
DOIs
Publication statusPublished - Dec 2016

Keywords

  • NORMATIVE DATA
  • CAROTID-ARTERY
  • PERFUSION
  • AGE
  • EDUCATION
  • VASOREACTIVITY
  • SEGMENTATION
  • PARTICIPANTS
  • IMPAIRMENT
  • FREQUENCY

Cite this

@article{031dcd4943cd420f87e52b9c48649fe4,
title = "Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus",
abstract = "We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.",
keywords = "NORMATIVE DATA, CAROTID-ARTERY, PERFUSION, AGE, EDUCATION, VASOREACTIVITY, SEGMENTATION, PARTICIPANTS, IMPAIRMENT, FREQUENCY",
author = "Jaap Jansen and {van Bussel}, {Frank C G} and {van de Haar}, {Harm J} and {van Osch}, {Matthias J P} and Hofman, {Paul A M} and {van Boxtel}, {Martin P J} and {van Oostenbrugge}, {Robert J} and Schram, {Miranda T} and Stehouwer, {Coen D A} and Wildberger, {Joachim E} and Backes, {Walter H}",
year = "2016",
month = "12",
doi = "10.1038/s41598-016-0003-6",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus. / Jansen, Jaap; van Bussel, Frank C G; van de Haar, Harm J; van Osch, Matthias J P; Hofman, Paul A M; van Boxtel, Martin P J; van Oostenbrugge, Robert J; Schram, Miranda T; Stehouwer, Coen D A; Wildberger, Joachim E; Backes, Walter H.

In: Scientific Reports, Vol. 6, No. 1, 10, 12.2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus

AU - Jansen, Jaap

AU - van Bussel, Frank C G

AU - van de Haar, Harm J

AU - van Osch, Matthias J P

AU - Hofman, Paul A M

AU - van Boxtel, Martin P J

AU - van Oostenbrugge, Robert J

AU - Schram, Miranda T

AU - Stehouwer, Coen D A

AU - Wildberger, Joachim E

AU - Backes, Walter H

PY - 2016/12

Y1 - 2016/12

N2 - We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.

AB - We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants with and thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) blood flow in the internal carotid artery and an arterial spin labeling technique measuring (microvascular) perfusion in the grey matter (GM). Three analysis methods were used to quantify the CBF: a region of interest analysis, a voxel-based statistical parametric mapping technique, and a 'distributed deviating voxels' method. Participants with T2DM exhibited significantly more tissue with low CBF values in the cerebral cortex and the subcortical GM (3.8-fold increase). The latter was the only region where the hypoperfusion remained after correcting for atrophy, indicating that the effect of T2DM on CBF, independent of atrophy, is small. Subcortical CBF was associated with depression. No associations were observed for CBF in other regions with diabetes status, for carotid blood flow with diabetes status, or for CBF or flow in relation with cognitive function. To conclude, a novel method that tallies total 'distributed deviating voxels' demonstrates T2DM-associated hypoperfusion in the subcortical GM, not associated with cognitive performance. Whether a vascular mechanism underlies cognitive decrements remains inconclusive.

KW - NORMATIVE DATA

KW - CAROTID-ARTERY

KW - PERFUSION

KW - AGE

KW - EDUCATION

KW - VASOREACTIVITY

KW - SEGMENTATION

KW - PARTICIPANTS

KW - IMPAIRMENT

KW - FREQUENCY

U2 - 10.1038/s41598-016-0003-6

DO - 10.1038/s41598-016-0003-6

M3 - Article

C2 - 27920431

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 10

ER -