TY - JOUR
T1 - Cerebral blood flow and cognitive functioning in patients with disorders along the heart-brain axis
T2 - Cerebral blood flow and the heart-brain axis
AU - Leeuwis, Anna E
AU - Hooghiemstra, Astrid M
AU - Bron, Esther E
AU - Kuipers, Sanne
AU - Oudeman, Eline A
AU - Kalay, Tugba
AU - Brunner-La Rocca, Hans-Peter
AU - Kappelle, L Jaap
AU - van Oostenbrugge, Robert J
AU - Greving, Jacoba P
AU - Niessen, Wiro J
AU - van Buchem, Mark A
AU - van Osch, Matthias J P
AU - van Rossum, Albert C
AU - Prins, Niels D
AU - Biessels, Geert-Jan
AU - Barkhof, Frederik
AU - van der Flier, Wiesje M
AU - Heart–Brain Connection consortium
N1 - © 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
PY - 2020
Y1 - 2020
N2 - Introduction: We examined the role of hemodynamic dysfunction in cognition by relating cerebral blood flow (CBF), measured with arterial spin labeling (ASL), to cognitive functioning, in patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance imaging (MRI; ie, possible vascular cognitive impairment [VCI]).Methods: We included 439 participants (124 HF; 75 COD; 127 possible VCI; 113 reference participants) from the Dutch multi-center Heart-Brain Study. We used pseudo-continuous ASL to estimate whole-brain and regional partial volume-corrected CBF. Neuropsychological tests covered global cognition and four cognitive domains.Results: CBF values were lowest in COD, followed by VCI and HF, compared to reference participants. This did not explain cognitive impairment, as we did not find an association between CBF and cognitive functioning.Discussion: We found that reduced CBF is not the major explanatory factor underlying cognitive impairment in patients with hemodynamic dysfunction along the heart-brain axis.
AB - Introduction: We examined the role of hemodynamic dysfunction in cognition by relating cerebral blood flow (CBF), measured with arterial spin labeling (ASL), to cognitive functioning, in patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance imaging (MRI; ie, possible vascular cognitive impairment [VCI]).Methods: We included 439 participants (124 HF; 75 COD; 127 possible VCI; 113 reference participants) from the Dutch multi-center Heart-Brain Study. We used pseudo-continuous ASL to estimate whole-brain and regional partial volume-corrected CBF. Neuropsychological tests covered global cognition and four cognitive domains.Results: CBF values were lowest in COD, followed by VCI and HF, compared to reference participants. This did not explain cognitive impairment, as we did not find an association between CBF and cognitive functioning.Discussion: We found that reduced CBF is not the major explanatory factor underlying cognitive impairment in patients with hemodynamic dysfunction along the heart-brain axis.
KW - carotid occlusive disease
KW - cognitive impairment
KW - heart failure
KW - perfusion
KW - small vessel disease
KW - vascular cognitive impairment
U2 - 10.1002/trc2.12034
DO - 10.1002/trc2.12034
M3 - Article
C2 - 32995468
SN - 2352-8737
VL - 6
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
M1 - e12034
ER -