TY - JOUR
T1 - Cerebral atrophy in elderly with subjective memory complaints
AU - Palm, Walter M.
AU - Ferrarini, Luca
AU - van der Flier, Wiesje M.
AU - Westendorp, Rudi G. J.
AU - Bollen, Eduard L. E. M.
AU - Middelkoop, Huub A. M.
AU - Milles, Julien R.
AU - van der Grond, Jeroen
AU - van Buchem, Mark A.
PY - 2013/8
Y1 - 2013/8
N2 - To evaluate ventricular shape differences along the complete surface of the lateral and third ventricles of persons with subjective memory complaints (MC).We included 28 controls and 21 persons with MC. FLAIR, T2, and PD-weighted brain MRI scans were acquired at 1.5 Tesla, followed by semi-automated segmentation of the lateral and third ventricles, and local shape difference analysis based on growing and adaptive meshes. Ventricular meshes were used to highlight local areas with significant differences between controls and persons with MC, determined by permutation tests with a predefined threshold (P = 0.01).Compared with control subjects, relevant differences were found in the shape of the ventricular surface adjacent to the thalamus and corona radiata in persons with MC. Before correction for multiple comparisons, relevant differences were also found in the shape of the ventricular surface adjacent to the corpus callosum, hippocampus, and amydala.Our findings suggest the presence of localized structural brain differences in patients with subjective memory complaints in the thalamus and the corona radiata.
AB - To evaluate ventricular shape differences along the complete surface of the lateral and third ventricles of persons with subjective memory complaints (MC).We included 28 controls and 21 persons with MC. FLAIR, T2, and PD-weighted brain MRI scans were acquired at 1.5 Tesla, followed by semi-automated segmentation of the lateral and third ventricles, and local shape difference analysis based on growing and adaptive meshes. Ventricular meshes were used to highlight local areas with significant differences between controls and persons with MC, determined by permutation tests with a predefined threshold (P = 0.01).Compared with control subjects, relevant differences were found in the shape of the ventricular surface adjacent to the thalamus and corona radiata in persons with MC. Before correction for multiple comparisons, relevant differences were also found in the shape of the ventricular surface adjacent to the corpus callosum, hippocampus, and amydala.Our findings suggest the presence of localized structural brain differences in patients with subjective memory complaints in the thalamus and the corona radiata.
KW - Subjective memory complaints
KW - ventricular shape
KW - thalamus
KW - corona radiata
U2 - 10.1002/jmri.23977
DO - 10.1002/jmri.23977
M3 - Article
C2 - 23239111
SN - 1053-1807
VL - 38
SP - 358
EP - 364
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 2
ER -