Cerebellar nuclei are activated by high-frequency stimulation of the subthalamic nucleus

Veronique M. P. Moers-Hornikx*, Johan S. H. Vles, Sonny K. H. Tan, Kimberly E. M. Cox-Limpens, Govert Hoogland, W. M. Harry Steinbusch, Yasin Temel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Web of Science)


The cerebellum, primarily considered a pure motor structure, is increasingly considered to play a role in behaviour and cognition. In a similar manner, there is increasing evidence that the basal ganglia are involved in non-motor processes. Recently a direct connection between the cerebellum and the basal ganglia has been shown to exist. High-frequency stimulation (HFS) of the subthalamic nucleus (STN) has become an accepted treatment in advanced Parkinson's disease (PD). We performed HFS of the STN in rats to evaluate the neuronal activation in the deep cerebellar nuclei (DCbN) using c-Fos immunohistochemistry. We found an increased c-Fos expression in the DCbN. Previously, we have shown that STN HFS in rats leads to decreased impulsive behaviour and our findings now suggest a link with increased DCbN activity. This is in line with our previous work showing that decreased DCbN activity is accompanied by disruptive behaviour. We suggest that the DCbN play a role in the selection of relevant information on which a behavioural response is based. The connection between the cerebellum and the basal ganglia may imply a role for the cerebellum in behavioural aspects of disorders of the basal ganglia.
Original languageEnglish
Pages (from-to)111-115
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 1 Jun 2011


  • Cerebellum
  • Deep brain stimulation
  • Subthalamic nucleus
  • Parkinson's disease

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