Cerebellar gray matter explains bimanual coordination performance in children and older adults

Matthieu P Boisgontier, Boris Cheval, Peter van Ruitenbeek, Koen Cuypers, Inge Leunissen, Stefan Sunaert, Raf Meesen, Hamed Zivari Adab, Olivier Renaud, Stephan P Swinnen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The cerebellum appears to undergo late maturation in children and early decline at older age. Whether these age-related changes affect bimanual coordination performance remains unclear at best. Here, we identified the ages at which bimanual coordination performance stops improving and starts declining. In an independent cohort, we defined brain regions of interest involved in bimanual coordination using functional magnetic resonance imaging. We used these regions of interest to investigate the extent to which the gray matter of cerebellar and other brain regions explains bimanual coordination performance from 10- to 80-year-olds. Results showed that bimanual coordination performance starts declining from the age of 40 years. In participants aged 10-20 years, cerebellar lobule VI was the only significant brain predictor of bimanual coordination performance. In participants aged 60-80 years, this cerebellar region, together with the primary sensorimotor cortex, formed a group of strongest predictors. These results from 2 independent samples (10-20 and 60-80 years) suggest that cerebellar lobule VI is critical for the development and preservation of bimanual coordination skills in children and older adults, respectively. In addition, post hoc analyses suggested that the primary motor cortex mediated the adverse effect of age on bimanual coordination performance in older adults.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalNeurobiology of Aging
Volume65
DOIs
Publication statusPublished - May 2018

Keywords

  • Adolescent development
  • Aging
  • Brain
  • Internal model
  • Magnetic resonance imaging
  • Movement
  • PHYSICAL-ACTIVITY QUESTIONNAIRE
  • AUGMENTED VISUAL FEEDBACK
  • AGE-RELATED DIFFERENCES
  • INTERNAL-MODELS
  • BASAL GANGLIA
  • WHITE-MATTER
  • COGNITIVE NEUROSCIENCE
  • SUBCORTICAL STRUCTURES
  • FUNCTIONAL TOPOGRAPHY
  • TASK-PERFORMANCE
  • Humans
  • Middle Aged
  • Male
  • Motor Cortex/diagnostic imaging
  • Cerebellum/diagnostic imaging
  • Gray Matter/diagnostic imaging
  • Young Adult
  • Aging/physiology
  • Aged, 80 and over
  • Adult
  • Female
  • Child
  • Magnetic Resonance Imaging
  • Adolescent
  • Aged
  • Psychomotor Performance/physiology
  • Cohort Studies

Cite this

Boisgontier, Matthieu P ; Cheval, Boris ; van Ruitenbeek, Peter ; Cuypers, Koen ; Leunissen, Inge ; Sunaert, Stefan ; Meesen, Raf ; Zivari Adab, Hamed ; Renaud, Olivier ; Swinnen, Stephan P. / Cerebellar gray matter explains bimanual coordination performance in children and older adults. In: Neurobiology of Aging. 2018 ; Vol. 65. pp. 109-120.
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title = "Cerebellar gray matter explains bimanual coordination performance in children and older adults",
abstract = "The cerebellum appears to undergo late maturation in children and early decline at older age. Whether these age-related changes affect bimanual coordination performance remains unclear at best. Here, we identified the ages at which bimanual coordination performance stops improving and starts declining. In an independent cohort, we defined brain regions of interest involved in bimanual coordination using functional magnetic resonance imaging. We used these regions of interest to investigate the extent to which the gray matter of cerebellar and other brain regions explains bimanual coordination performance from 10- to 80-year-olds. Results showed that bimanual coordination performance starts declining from the age of 40 years. In participants aged 10-20 years, cerebellar lobule VI was the only significant brain predictor of bimanual coordination performance. In participants aged 60-80 years, this cerebellar region, together with the primary sensorimotor cortex, formed a group of strongest predictors. These results from 2 independent samples (10-20 and 60-80 years) suggest that cerebellar lobule VI is critical for the development and preservation of bimanual coordination skills in children and older adults, respectively. In addition, post hoc analyses suggested that the primary motor cortex mediated the adverse effect of age on bimanual coordination performance in older adults.",
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author = "Boisgontier, {Matthieu P} and Boris Cheval and {van Ruitenbeek}, Peter and Koen Cuypers and Inge Leunissen and Stefan Sunaert and Raf Meesen and {Zivari Adab}, Hamed and Olivier Renaud and Swinnen, {Stephan P}",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
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language = "English",
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Boisgontier, MP, Cheval, B, van Ruitenbeek, P, Cuypers, K, Leunissen, I, Sunaert, S, Meesen, R, Zivari Adab, H, Renaud, O & Swinnen, SP 2018, 'Cerebellar gray matter explains bimanual coordination performance in children and older adults', Neurobiology of Aging, vol. 65, pp. 109-120. https://doi.org/10.1016/j.neurobiolaging.2018.01.016

Cerebellar gray matter explains bimanual coordination performance in children and older adults. / Boisgontier, Matthieu P; Cheval, Boris; van Ruitenbeek, Peter; Cuypers, Koen; Leunissen, Inge; Sunaert, Stefan; Meesen, Raf; Zivari Adab, Hamed; Renaud, Olivier; Swinnen, Stephan P.

In: Neurobiology of Aging, Vol. 65, 05.2018, p. 109-120.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebellar gray matter explains bimanual coordination performance in children and older adults

AU - Boisgontier, Matthieu P

AU - Cheval, Boris

AU - van Ruitenbeek, Peter

AU - Cuypers, Koen

AU - Leunissen, Inge

AU - Sunaert, Stefan

AU - Meesen, Raf

AU - Zivari Adab, Hamed

AU - Renaud, Olivier

AU - Swinnen, Stephan P

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - The cerebellum appears to undergo late maturation in children and early decline at older age. Whether these age-related changes affect bimanual coordination performance remains unclear at best. Here, we identified the ages at which bimanual coordination performance stops improving and starts declining. In an independent cohort, we defined brain regions of interest involved in bimanual coordination using functional magnetic resonance imaging. We used these regions of interest to investigate the extent to which the gray matter of cerebellar and other brain regions explains bimanual coordination performance from 10- to 80-year-olds. Results showed that bimanual coordination performance starts declining from the age of 40 years. In participants aged 10-20 years, cerebellar lobule VI was the only significant brain predictor of bimanual coordination performance. In participants aged 60-80 years, this cerebellar region, together with the primary sensorimotor cortex, formed a group of strongest predictors. These results from 2 independent samples (10-20 and 60-80 years) suggest that cerebellar lobule VI is critical for the development and preservation of bimanual coordination skills in children and older adults, respectively. In addition, post hoc analyses suggested that the primary motor cortex mediated the adverse effect of age on bimanual coordination performance in older adults.

AB - The cerebellum appears to undergo late maturation in children and early decline at older age. Whether these age-related changes affect bimanual coordination performance remains unclear at best. Here, we identified the ages at which bimanual coordination performance stops improving and starts declining. In an independent cohort, we defined brain regions of interest involved in bimanual coordination using functional magnetic resonance imaging. We used these regions of interest to investigate the extent to which the gray matter of cerebellar and other brain regions explains bimanual coordination performance from 10- to 80-year-olds. Results showed that bimanual coordination performance starts declining from the age of 40 years. In participants aged 10-20 years, cerebellar lobule VI was the only significant brain predictor of bimanual coordination performance. In participants aged 60-80 years, this cerebellar region, together with the primary sensorimotor cortex, formed a group of strongest predictors. These results from 2 independent samples (10-20 and 60-80 years) suggest that cerebellar lobule VI is critical for the development and preservation of bimanual coordination skills in children and older adults, respectively. In addition, post hoc analyses suggested that the primary motor cortex mediated the adverse effect of age on bimanual coordination performance in older adults.

KW - Adolescent development

KW - Aging

KW - Brain

KW - Internal model

KW - Magnetic resonance imaging

KW - Movement

KW - PHYSICAL-ACTIVITY QUESTIONNAIRE

KW - AUGMENTED VISUAL FEEDBACK

KW - AGE-RELATED DIFFERENCES

KW - INTERNAL-MODELS

KW - BASAL GANGLIA

KW - WHITE-MATTER

KW - COGNITIVE NEUROSCIENCE

KW - SUBCORTICAL STRUCTURES

KW - FUNCTIONAL TOPOGRAPHY

KW - TASK-PERFORMANCE

KW - Humans

KW - Middle Aged

KW - Male

KW - Motor Cortex/diagnostic imaging

KW - Cerebellum/diagnostic imaging

KW - Gray Matter/diagnostic imaging

KW - Young Adult

KW - Aging/physiology

KW - Aged, 80 and over

KW - Adult

KW - Female

KW - Child

KW - Magnetic Resonance Imaging

KW - Adolescent

KW - Aged

KW - Psychomotor Performance/physiology

KW - Cohort Studies

U2 - 10.1016/j.neurobiolaging.2018.01.016

DO - 10.1016/j.neurobiolaging.2018.01.016

M3 - Article

C2 - 29471213

VL - 65

SP - 109

EP - 120

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -