Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective

Ana P Pinheiro*, Michael Schwartze, Sonja A Kotz

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

6 Citations (Web of Science)
107 Downloads (Pure)

Abstract

Auditory verbal hallucinations (AVH) - experienced as voice hearing independent of a corresponding external sound source - are a cardinal symptom of psychosis. Approximately 6-13% of healthy individuals also experience voice hearing. Despite numerous attempts to explain the neurofunctional mechanisms underlying AVH, they remain notoriously unexplained. However, evidence relates AVH to mechanistic changes in the forward model. This review synthesizes behavioral and neuroimaging studies exploring the central role of cerebellar circuitry in the forward model, with a particular focus on non-verbal and verbal auditory feedback. It confirms that erratic prediction of sensory consequences in voice and sound production is linked to impaired cerebellar function, which initiates AVH and affects higher-level cognitive functions. We propose new research directions linking the forward model to voice and sound feedback processing. We consider this review as a starting point for mapping mechanisms of the forward model to neurocognitive mechanisms underlying AVH.

Original languageEnglish
Pages (from-to)485-503
Number of pages19
JournalNeuroscience and Biobehavioral Reviews
Volume118
Early online date15 Aug 2020
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Auditory verbal hallucinations
  • CLINICAL-HIGH-RISK
  • COROLLARY DISCHARGE DYSFUNCTION
  • Cerebellum
  • Cognition
  • Forward model
  • INNER SPEECH
  • INTERNAL-MODELS
  • MOVEMENT-RELATED POTENTIALS
  • Psychosis continuum
  • SELF-INITIATED SOUNDS
  • SENSORY PREDICTION ERRORS
  • SUPPLEMENTARY MOTOR AREA
  • ULTRA-HIGH-RISK
  • VOICE-SELECTIVE AREAS
  • NAIVE SCHIZOPHRENIA-PATIENTS
  • FUNCTIONAL CONNECTIVITY

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