@article{f70ca079c361469d9bac5ad2db7cf335,
title = "Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research",
abstract = "Observer variability in local radiological reading is a major concern in large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of this study is to compare central with local reading of TBI imaging datasets and to investigate the added value of central review. A total of 2050 admission computed tomography (CT) scans from subjects enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study were analyzed for seven main CT characteristics. Kappa statistics were used to calculate agreement between central and local evaluations and a center-specific analysis was performed. The McNemar test was used to detect whether discordances were significant. Central interobserver and intra-observer agreement was calculated in a subset of patients. Good agreement was found between central and local assessment for the presence or absence of structural pathology (CT+, CT-, kappa = 0.73) and most CT characteristics (kappa = 0.62 to 0.71), except for traumatic axonal injury lesions (kappa = 0.37). Despite good kappa values, discordances were significant in four of seven CT characteristics (i.e., midline shift, contusion, traumatic subarachnoid hemorrhage, and cisternal compression; p = 0.0005). Central reviewers showed substantial to excellent interobserver and intra-observer agreement (kappa = 0.73 to kappa = 0.96), contrasted by considerable variability in local radiological reading. Compared with local evaluation, a central review process offers a more consistent radiological reading of acute CT characteristics in TBI. It generates reliable, reproducible data and should be recommended for use in multi-center TBI studies.",
keywords = "agreement, central radiology review, traumatic brain injury, COMMON DATA ELEMENTS, PROGNOSTIC VALUE, HEAD-INJURY, CT, HEMORRHAGE, DIAGNOSIS, FEATURES, SCAN",
author = "{Vande Vyvere}, Thijs and Guido Wilms and Lene Claes and Leon, {Francisco Martin} and Daan Nieboer and Jan Verheyden and {van den Hauwe}, Luc and Pim Pullens and Maas, {Andrew I. R.} and Parizel, {Paul M.} and {CENTER-TBI Investigators} and {van Heugten}, {Caroline M.}",
note = "Funding Information: Data used in preparation of this manuscript were obtained in the context of CENTER-TBI, a large collaborative project supported by the European Commission 7th Framework program (602150). Funding of additional elements has been provided by the Hannelore Kohl Foundation (Germany) and by the non-profit organization One Mind. Funding Information: 3Department of Anesthesia and Intensive Care, M. Bufalini Hospital, Cesena, Italy. 4Department of Clinical Neurosciences, Addenbrooke{\textquoteright}s Hospital and University of Cambridge, Cambridge, United Kingdom. 5J{\'a}nos Szent{\'a}gothai Research Centre, University of P{\'e}cs, P{\'e}cs, Hungary. 6University of Cincinnati, Cincinnati, Ohio. 7Division of Surgery and Clinical Neuroscience, Department of Physical Medicine and Rehabilitation, Oslo University Hospital and University of Oslo, Oslo, Norway. 8Department of Neurosurgery, University Hospital Northern Norway, Tromso, Norway. 9Department of Neurosurgery, Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. 10Department of Physical Medicine and Rehabilitation, University Hospital, Northern Norway. 11Trauma Surgery, Medical University Vienna, Vienna, Austria. 12Department of Neurosurgery, Elisabeth-Tweesteden Zie-kenhuis, Tilburg, the Netherlands. 13Department of Anesthesiology and Intensive Care, University Hospital Nancy, Nancy, France. 14Riga Eastern Clinical University Hospital, Riga, Latvia. 15Raymond Poincare hospital, Assistance Publique—Hopitaux de Paris, Paris, France. 16Department of Anesthesiology and Intensive Care, San Raf-faele University Hospital, Milan, Italy. 17NeuroIntensive Care, Niguarda Hospital, Milan, Italy. 18Department Anesthesiology and Surgical-Trauma Intensive Care, Hospital Clinic Universitari de Valencia, Spain. 19Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands. 20Department of Neurosurgery, University of Szeged, Szeged, Hungary. 21Institute for Transfusion Medicine (ITM), Witten/Herdecke University, Cologne, Germany. 22International Projects Management, ARTTIC, Munchen, Germany. 23Department of Neurology, Neurological Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria. 24Department of Neurosurgery and Anesthesia and intensive care medicine, Karolinska University Hospital, Stockholm, Sweden. 25NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, U.K 26Intensive Care Unit, CHU Poitiers, Poitiers, France. 27Anesthesie-R{\'e}animation, Assistance Publique—Hopitaux de Paris, Paris, France. 28Department of Anesthesia and ICU, AOU Citt{\`a} della Salute e della Scienza di Torino— Orthopedic and Trauma Center, Torino, Italy. 29Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany. 30Department of Neurology, Odense University Hospital, Odense, Denmark. 31Department of Anesthesiology and Intensive Care, University Hospital of Grenoble, Grenoble, France. 32BehaviourWorks Australia, Monash Sustainability Institute, Monash University, Victoria, Australia. 33Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia. 34Quesgen Systems Inc., Burlingame, California. 35Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. 36Department of Neurosurgery, Umea University Hospital, Umea, Sweden. 37Department of Neurosurgery, University of Pecs and MTA-PTE Clinical Neuroscience MR Research Group and Janos Szen-tagothai Research Centre, University of Pecs, Hungarian Brain Research Program, Pecs, Hungary. 38Department of Medical Psychology, Universit{\"a}tsklinikum Hamburg-Eppendorf, Hamburg, Germany. 39Neuro ICU, Fondazione IRCCS C{\`a} Granda Ospedale Maggiore Policlinico, Milan, Italy. 40ANZIC Research Centre, Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Vitoria, Australia. 41Department of Neurosurgery, Hospital of Cruces, Bilbao, Spain. 42Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children{\textquoteright}s Hospital, Rotterdam, the Netherlands. 43Department of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Spain. 44Department of Neuroscience, Azienda Ospedaliera Universit{\`a} di Padova, Padova, Italy 45NeuroIntensive Care, ASST di Monza, Monza, Italy. 46School of Medicine and Surgery, Universit{\`a} Milano Bicocca, Milano, Italy. 47Department of Public Health, Erasmus Medical Center-University Medical Center, Rotterdam, the Netherlands. 48Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany. 49Department of Anesthesia and Neurointensive Care, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom. 50Movement Science Group, Oxford Institute of Nursing, Midwifery and Allied Health Research, Oxford Brookes University, Oxford, United Kingdom. 51School of Public Health and PM, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia. 52Radiology/MRI department, MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom. 53Institute of Medical Psychology and Medical Sociology, Universit{\"a}tsmedizin G{\"o}ttingen, G{\"o}ttingen, Germany. 54Oxford University Hospitals NHS Trust, Oxford, United Kingdom. 55Department of Neurosurgery, University of Pecs and MTA-PTE Clinical Neuroscience MR Research Group and Janos Szentagothai Research Centre, University of Pecs, Hungarian Brain Research Program (Grant No. KTIA 13 NAP-A-II/8), Pecs, Hungary. 56Brain Physics Lab, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke{\textquoteright}s Hospital, Cambridge, United Kingdom. 57Intensive Care Unit, CHR Citadelle, Li{\`e}ge, Belgium. 58Intensive Care Unit, CHU, Li{\`e}ge, Belgium. 59Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, United Kingdom. 60Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium. 61Department of Anesthesia and Intensive Care, Maggiore Della Carit{\`a} Hospital, Novara, Italy. 62Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium. Publisher Copyright: {\textcopyright} 2019 Mary Ann Liebert, Inc., publishers.",
year = "2019",
month = apr,
doi = "10.1089/neu.2018.6061",
language = "English",
volume = "36",
pages = "1080--1092",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "7",
}