Central hemodynamics in relation to low-level environmental lead exposure

Cai-Guo Yu, Fang-Fei Wei, Zhen-Yu Zhang, Lutgarde Thijs, Wen-Yi Yang, Blerim Mujaj, Ying-Mei Feng, Jose Boggia, Harry A. Roels, Harry A. J. Struijker-Boudier, Tim S. Nawrot, Peter Verhamme, Jan A. Staessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Purpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish population. Materials and Methods: In this Flemish population study (mean age, 37.0 years; 48.3% women), 267 participants had their whole BL and 24-h urinary cadmium (UCd) measured by electrothermal atomic absorption spectrometry in 1985-2005. After 9.4 years (median), they underwent applanation tonometry to estimate central pulse pressure (cPP), the augmentation index (AI), pressure amplification (PA), and aPWV. The amplitudes of the forward (Pf) and backward (Pb) pulse waves and reflection index (RI) were derived by a pressure-based wave separation algorithm. Results: BL averaged 2.93 mu g/dL (interquartile range, 1.80-4.70) and UCd 4.79 mu g (2.91-7.85). Mean values were 45.0 +/- 15.2 mm Hg for cPP, 24.4 +/- 12.4% for AI, 1.34 +/- 0.21 for PA, 7.65 +/- 1.74 m/s for aPWV, 32.7 +/- 9.9 mm Hg for Pf, 21.8 +/- 8.4 mm Hg for Pb, and 66.9 +/- 18.4% for RI. The multivariable-adjusted association sizes for a 2-fold higher BL were: +3.03% (95% confidence interval, 1.56, 4.50) for AI; -0.06 (-0.08, -0.04) for PA; 1.02 mm Hg (0.02, 2.02) for Pb; and 3.98% (1.71, 6.24) for RI (p

Original languageEnglish
Pages (from-to)157-167
Number of pages11
JournalBlood Pressure
Volume29
Issue number3
Early online date13 Dec 2019
DOIs
Publication statusPublished - 3 May 2020

Keywords

  • arterial stiffness
  • central blood pressure
  • central hemodynamics
  • lead
  • environmental medicine
  • PULSE-WAVE VELOCITY
  • AMBULATORY BLOOD-PRESSURE
  • ARTERIAL STIFFNESS
  • RISK-FACTORS
  • CADMIUM
  • REFLECTION
  • HYPERTENSION
  • ASSOCIATION
  • PREVALENCE
  • COMMUNITY

Cite this