Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review

Daan W. A. van den Nieuwenhof; Lorenzo Moroni; Joshua Chou; Jochen Hinkelbein

doi:10.1038/s41526-024-00442-z

Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review

Daan W. A. van den Nieuwenhof^*, Lorenzo Moroni, Joshua Chou, Jochen Hinkelbein

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.

Original language	English
Article number	102
Number of pages	16
Journal	NPJ Microgravity
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41526-024-00442-z
Publication status	Published - 6 Nov 2024

Keywords

EMBRYONIC STEM-CELLS
THYROID-CANCER CELLS
ENDOTHELIAL-CELLS
CULTURE
BONE
SPACE
GROWTH
DIFFERENTIATION
CONSTRUCTS
BIOREACTOR

Access to Document

10.1038/s41526-024-00442-zLicence: CC BY-NC-ND

Cite this

@article{e5c1fbdf9ae643c5b963586c37ca3d17,

title = "Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review",

abstract = "The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.",

keywords = "EMBRYONIC STEM-CELLS, THYROID-CANCER CELLS, ENDOTHELIAL-CELLS, CULTURE, BONE, SPACE, GROWTH, DIFFERENTIATION, CONSTRUCTS, BIOREACTOR",

author = "{van den Nieuwenhof}, {Daan W. A.} and Lorenzo Moroni and Joshua Chou and Jochen Hinkelbein",

year = "2024",

month = nov,

day = "6",

doi = "10.1038/s41526-024-00442-z",

language = "English",

volume = "10",

journal = "NPJ Microgravity",

issn = "2373-8065",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity

T2 - a narrative review

AU - van den Nieuwenhof, Daan W. A.

AU - Moroni, Lorenzo

AU - Chou, Joshua

AU - Hinkelbein, Jochen

PY - 2024/11/6

Y1 - 2024/11/6

N2 - The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.

AB - The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.

KW - EMBRYONIC STEM-CELLS

KW - THYROID-CANCER CELLS

KW - ENDOTHELIAL-CELLS

KW - CULTURE

KW - BONE

KW - SPACE

KW - GROWTH

KW - DIFFERENTIATION

KW - CONSTRUCTS

KW - BIOREACTOR

U2 - 10.1038/s41526-024-00442-z

DO - 10.1038/s41526-024-00442-z

M3 - (Systematic) Review article

SN - 2373-8065

VL - 10

JO - NPJ Microgravity

JF - NPJ Microgravity

IS - 1

M1 - 102

ER -

Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review

Abstract

Keywords

Access to Document

Fingerprint

Cite this