Cellular immunotherapy : from stem cell to lymphocyte

M.J.A.J. Huijskens

Research output: ThesisDoctoral ThesisInternal

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To reduce the mortality rate in cancer patients who undergo stem cell transplantation, a study was conducted on the development of cellular immunotherapy using immature T-cells to strengthen the immune system after treatment. A clinically applicable system was developed for producing these cells from stem cells. It was found that vitamin C significantly improved production and brought about greater cell yield for therapeutic purposes. It was also found that patients with haematological malignancy (i.e. certain forms of cancer, including leukaemia) had lower vitamin C levels. Administering vitamin C may therefore promote immune recovery.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Bos, Gerardus, Supervisor
  • Kawamoto, H., Supervisor, External person
  • Germeraad, Wilfred, Co-Supervisor
Award date12 Feb 2015
Place of PublicationMaastricht
Print ISBNs9789461088949
Publication statusPublished - 2015


  • immune system
  • stem cell transplantation
  • immunotherapy
  • vitamin C

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