Cellular effects and clinical implications of SLC2A3 copy number variation

Georg C. Ziegler*, Peter Almos, Rhiannon V. McNeill, Charline Jansch, Klaus-Peter Lesch

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Web of Science)

Abstract

SLC2A3 encodes the predominantly neuronal glucose transporter 3 (GLUT3), which facilitates diffusion of glucose across plasma membranes. The human brain depends on a steady glucose supply for ATP generation, which consequently fuels critical biochemical processes, such as axonal transport and neurotransmitter release. Besides its role in the central nervous system, GLUT3 is also expressed in nonneural organs, such as the heart and white blood cells, where it is equally involved in energy metabolism. In cancer cells, GLUT3 overexpression contributes to the Warburg effect by answering the cell's increased glycolytic demands. The SLC2A3 gene locus at chromosome 12p13.31 is unstable and prone to non-allelic homologous recombination events, generating multiple copy number variants (CNVs) of SLC2A3 which account for alterations in SLC2A3 expression. Recent associations of SLC2A3 CNVs with different clinical phenotypes warrant investigation of the potential influence of these structural variants on pathomechanisms of neuropsychiatric, cardiovascular, and immune diseases. In this review, we accumulate and discuss the evidence how SLC2A3 gene dosage may exert diverse protective or detrimental effects depending on the pathological condition. Cellular states which lead to increased energetic demand, such as organ development, proliferation, and cellular degeneration, appear particularly susceptible to alterations in SLC2A3 copy number. We conclude that better understanding of the impact of SLC2A3 variation on disease etiology may potentially provide novel therapeutic approaches specifically targeting this GLUT.

Original languageEnglish
Pages (from-to)9021-9036
Number of pages16
JournalJournal of Cellular Physiology
Volume235
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • copy number variation
  • energy metabolism
  • glucose transporter
  • GLUT3
  • neurodegeneration
  • neurodevelopment
  • GLUCOSE-TRANSPORTER GLUT3
  • CONGENITAL HEART-DISEASE
  • BRAIN WHITE-MATTER
  • SUBSTRATE SPECIFICITIES
  • RHEUMATOID-ARTHRITIS
  • GENE-EXPRESSION
  • XENOPUS OOCYTES
  • METABOLISM
  • PROTEIN
  • LOCALIZATION

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