TY - JOUR
T1 - Cell-laden alginate hydrogels for the treatment of diabetes
AU - Izeia, Lukin
AU - Eufrasio-da-Silva, Tatiane
AU - Dolatshahi-Pirouz, Alireza
AU - Ostrovidov, Serge
AU - Paolone, Giovanna
AU - Peppas, Nicholas A.
AU - De Vos, Paul
AU - Emerich, Dwaine
AU - Orive, Gorka
PY - 2020/8/2
Y1 - 2020/8/2
N2 - Introduction Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry. Area covered The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed. Expert opinion Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.
AB - Introduction Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry. Area covered The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed. Expert opinion Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.
KW - Diabetes mellitus
KW - Alginate
KW - Cell encapsulation
KW - Cell-laden hydrogels
KW - Drug delivery
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=researchintelligenceproject&SrcAuth=WosAPI&KeyUT=WOS:000558836300006&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1080/17425247.2020.1778667
DO - 10.1080/17425247.2020.1778667
M3 - (Systematic) Review article
C2 - 32515621
SN - 1742-5247
VL - 17
SP - 1113
EP - 1118
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
IS - 8
ER -