Celivarone for Maintenance of Sinus Rhythm and Conversion of Atrial Fibrillation/Flutter

Avinash R. Khitri*, Etienne M. Aliot, Alessandro Capucci, Stuart J. Connolly, Harry Crijns, Stefan H. Hohnloser, Piotr Kulakowski, Denis Roy, David Radzik, Peter R. Kowey

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Celivarone in Atrial Fibrillation/Atrial Flutter. Introduction: Celivarone, a new noniodinated benzofuran derivative pharmacologically related to dronedarone and amiodarone, has been shown to have antiarrhythmic properties at a molecular level. The purpose of the 2 trials presented here (MAIA and CORYFEE) was to assess celivarone efficacy in the maintenance of sinus rhythm postcardioversion and for the conversion of atrial fibrillation (AF)/atrial flutter (AFL). Methods and Results: In the MAIA trial, 673 patients with AF/AFL recently converted to sinus rhythm were randomly assigned to receive 50, 100, 200, or 300 mg once-daily dosing of celivarone; 200 mg daily of amiodarone preceded by a loading dose of 600 mg for 10 days; or placebo. At 3 months follow up, no significant difference was observed in time to AF/AFL relapse among the various celivarone groups and placebo. However, fewer symptomatic AF/AFL recurrences were observed in the lower-dose celivarone groups (26.6% for celivarone 50 mg [P = 0.022] and 25.2% for celivarone 100 mg [P = 0.018] vs 40.5% for placebo at 90 days). Fewer adverse events were observed with the use of celivarone and placebo than amiodarone. In the CORYFEE study, 150 patients with AF/AFL were randomly assigned to once-daily celivarone dosing of 300 or 600 mg, or placebo, for a 2-day treatment period. There was no significant difference in the rate of spontaneous conversion to sinus rhythm between the treatment and control groups. Conclusions: In these studies, celivarone does not appear to be efficacious in the maintenance of sinus rhythm in AF/AFL patients or for the conversion of AF/AFL patients. (J Cardiovasc Electrophysiol, Vol. 23, pp. 462-472, May 2012)
Original languageEnglish
Pages (from-to)462-472
JournalJournal of Cardiovascular Electrophysiology
Issue number5
Publication statusPublished - May 2012


  • amiodarone
  • atrial fibrillation
  • atrial flutter
  • celivarone
  • conversion
  • dronedarone
  • maintenance


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