CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

M. O. Versteylen; M. Manca; I. A. Joosen; D. E. Schmidt; Marco Das; L. Hofstra; H. J. Crijns; E. A. Biessen; B. L. Kietselaer

doi:10.1007/s12471-016-0884-9

CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

M. O. Versteylen^*, M. Manca, I. A. Joosen, D. E. Schmidt, Marco Das, L. Hofstra, H. J. Crijns, E. A. Biessen, B. L. Kietselaer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Web of Science)

Abstract

Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with

Original language	English
Pages (from-to)	722-729
Number of pages	8
Journal	Netherlands Heart Journal
Volume	24
Issue number	12
DOIs	https://doi.org/10.1007/s12471-016-0884-9
Publication status	Published - Dec 2016

Keywords

CC chemokine ligands
Cardiac computed tomographic angiography
Coronary artery disease
Cardiac events
Prognosis

Access to Document

10.1007/s12471-016-0884-9

Cite this

@article{40cade4169be44168204f8b21b7fe928,

title = "CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events",

abstract = "Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with ",

keywords = "CC chemokine ligands, Cardiac computed tomographic angiography, Coronary artery disease, Cardiac events, Prognosis",

author = "Versteylen, {M. O.} and M. Manca and Joosen, {I. A.} and Schmidt, {D. E.} and Marco Das and L. Hofstra and Crijns, {H. J.} and Biessen, {E. A.} and Kietselaer, {B. L.}",

year = "2016",

month = dec,

doi = "10.1007/s12471-016-0884-9",

language = "English",

volume = "24",

pages = "722--729",

journal = "Netherlands Heart Journal",

issn = "1568-5888",

publisher = "Bohn Stafleu van Loghum",

number = "12",

}

TY - JOUR

T1 - CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

AU - Versteylen, M. O.

AU - Manca, M.

AU - Joosen, I. A.

AU - Schmidt, D. E.

AU - Das, Marco

AU - Hofstra, L.

AU - Crijns, H. J.

AU - Biessen, E. A.

AU - Kietselaer, B. L.

PY - 2016/12

Y1 - 2016/12

N2 - Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with

AB - Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with

KW - CC chemokine ligands

KW - Cardiac computed tomographic angiography

KW - Coronary artery disease

KW - Cardiac events

KW - Prognosis

U2 - 10.1007/s12471-016-0884-9

DO - 10.1007/s12471-016-0884-9

M3 - Article

C2 - 27573044

VL - 24

SP - 722

EP - 729

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

SN - 1568-5888

IS - 12

ER -