CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

M. O. Versteylen*, M. Manca, I. A. Joosen, D. E. Schmidt, Marco Das, L. Hofstra, H. J. Crijns, E. A. Biessen, B. L. Kietselaer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)


Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with
Original languageEnglish
Pages (from-to)722-729
Number of pages8
JournalNetherlands Heart Journal
Issue number12
Publication statusPublished - Dec 2016


  • CC chemokine ligands
  • Cardiac computed tomographic angiography
  • Coronary artery disease
  • Cardiac events
  • Prognosis

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