CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

M. O. Versteylen; M. Manca; I. A. Joosen; D. E. Schmidt; Marco Das; L. Hofstra; H. J. Crijns; E. A. Biessen; B. L. Kietselaer

doi:10.1007/s12471-016-0884-9

CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

M. O. Versteylen^*, M. Manca, I. A. Joosen, D. E. Schmidt, Marco Das, L. Hofstra, H. J. Crijns, E. A. Biessen, B. L. Kietselaer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with

Original language	English
Pages (from-to)	722-729
Number of pages	8
Journal	Netherlands Heart Journal
Volume	24
Issue number	12
DOIs	https://doi.org/10.1007/s12471-016-0884-9
Publication status	Published - Dec 2016

Keywords

CC chemokine ligands
Cardiac computed tomographic angiography
Coronary artery disease
Cardiac events
Prognosis

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10.1007/s12471-016-0884-9Licence: CC BY

Cite this

@article{40cade4169be44168204f8b21b7fe928,

title = "CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events",

abstract = "Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with ",

keywords = "CC chemokine ligands, Cardiac computed tomographic angiography, Coronary artery disease, Cardiac events, Prognosis",

author = "Versteylen, {M. O.} and M. Manca and Joosen, {I. A.} and Schmidt, {D. E.} and Marco Das and L. Hofstra and Crijns, {H. J.} and Biessen, {E. A.} and Kietselaer, {B. L.}",

year = "2016",

month = dec,

doi = "10.1007/s12471-016-0884-9",

language = "English",

volume = "24",

pages = "722--729",

journal = "Netherlands Heart Journal",

issn = "1568-5888",

publisher = "Bohn Stafleu van Loghum",

number = "12",

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TY - JOUR

T1 - CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events

AU - Versteylen, M. O.

AU - Manca, M.

AU - Joosen, I. A.

AU - Schmidt, D. E.

AU - Das, Marco

AU - Hofstra, L.

AU - Crijns, H. J.

AU - Biessen, E. A.

AU - Kietselaer, B. L.

PY - 2016/12

Y1 - 2016/12

N2 - Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with

AB - Background CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 are linked to the extent of coronary artery disease (CAD) and prognostic for primary events during follow-up. Methods We measured CCL3-5-18 serum concentrations in 712 patients with chest discomfort referred for cardiac CT angiography. Obstructive CAD was defined as >= 50% stenosis. The extent of CAD was measured by calcium score and segment involvement score (number of coronary segments with any CAD, range 0-16). Patients were followed up for all-cause mortality, ACS and revascularisation, for a mean 26 +/- 7 months. Results Patients with obstructive CAD had significantly higher CCL5 (p = 0.02), and borderline significantly elevated CCL18 plasma levels as compared with patients with

KW - CC chemokine ligands

KW - Cardiac computed tomographic angiography

KW - Coronary artery disease

KW - Cardiac events

KW - Prognosis

U2 - 10.1007/s12471-016-0884-9

DO - 10.1007/s12471-016-0884-9

M3 - Article

C2 - 27573044

SN - 1568-5888

VL - 24

SP - 722

EP - 729

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

IS - 12

ER -