Abstract
Background-Atrial fibrillation (AF) leads to structural and neural remodeling in the atrium, which enhances AF complexity and perpetuation. Renal denervation (RDN) can reduce renal and whole-body sympathetic activity. Aim of this study was to determine the effect of sympathetic nervous system modulation by RDN on atrial arrhythmogenesis. Methods and Result-Eighteen goats were instrumented with an atrial endocardial pacemaker lead and a burst pacemaker. Percutaneous catheter-based RDN was performed in 8 goats (RDN-AF). Ten goats undergoing a sham procedure served as control (SHAM-AF). AF was induced and maintained by burst pacing for 6 weeks. High-resolution mapping was used to record epicardial conduction patterns of the right and left atrium. RDN reduced tyrosine hydroxylase-positive sympathetic nerve staining and resulted in lower transcardiac norepinephrine levels. This was associated with reduced expression of nerve growth factor-beta, indicating less atrial nerve sprouting. Atrial endomysial fibrosis content was lower and myocyte diameter was smaller in RDN-AF. Median conduction velocity was higher (75+/-9 versus 65+/-10 cm/s, P=0.02), and AF cycle length was shorter in RDN-AF compared with SHAM-AF. Left atrial AF complexity (4.8+/-0.8 fibrillation waves/AF cycle length versus 8.5+/-0.8 waves/AF cycle length, P=0.001) and incidence of breakthroughs (2.0+/-0.3 versus 4.3+/-0.5 waves/AF cycle length, P=0.059) were lower in RDN-AF compared with SHAM-AF. Blood pressure was normal and not significantly different between the groups. Conclusions-RDN reduces atrial sympathetic nerve sprouting, structural alterations, and AF complexity in goats with persistent AF, independent of changes in blood pressure.
Original language | English |
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Pages (from-to) | 466-U294 |
Journal | Circulation-Arrhythmia and Electrophysiology |
Volume | 8 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2015 |
Keywords
- atrial fibrillation
- autonomic nervous system
- complexity
- mapping
- nerve sprouting
- remodeling
- renal denervation